Occupational asbestos exposure as a risk factor for laryngeal carcinoma in a population-based case-control study from Germany
| Autor: | Wolfgang Ahrens, Andreas Dietz, Heiko Becher, Heribert Ramroth |
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| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Occupational risk Population Population based medicine.disease_cause Asbestos Risk Factors Environmental health Germany Occupational Exposure Surveys and Questionnaires Carcinoma medicine Confidence Intervals Odds Ratio Humans Risk factor education Laryngeal Neoplasms Aged education.field_of_study business.industry Public Health Environmental and Occupational Health Case-control study Cancer Middle Aged medicine.disease Surgery Occupational Diseases Logistic Models Case-Control Studies Female business |
| Zdroj: | American journal of industrial medicine. 54(7) |
| ISSN: | 1097-0274 |
| Popis: | Background As several studies have identified asbestos exposure as an independent occupational risk factor for laryngeal cancer, the aim of our study was to confirm this association. Methods In a population-based case–control study on laryngeal cancer in South-West Germany occupational exposures and other risk factors were obtained by face-to-face interviews using a detailed standardized questionnaire covering the complete individual working history, supplemented by job-specific questionnaires (JSQ) especially for selected jobs known to entail exposure to asbestos. Detailed exposure information was collected over a wide range of asbestos related jobs and branches and analyzed using different modeling strategies. Results Seventy-three (28.4%) cases and 158 (20.5%) controls reported any exposure to asbestos. Elevated risk estimates for asbestos exposure were found. However, those became substantially reduced after adjustment for smoking and alcohol. Conclusion Moderately elevated risks for laryngeal cancer after exposure to asbestos were confirmed. Difficulties in the collection of adequate exposure data were demonstrated. Am. J. Ind. Med. 54:510–514, 2011. © 2011 Wiley-Liss, Inc. |
| Databáze: | OpenAIRE |
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