Nasal wall compliance in vasomotor rhinitis
| Autor: | André Coste, Céline Croce, Daniel Isabey, Michel Rugina, Christrian Larger, Redouane Fodil, Lydia Brugel-Ribere, Jean-François Papon, Bruno Louis, Françoise Zerah-Lancner |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Male Rhinometry Acoustic Physiology Oxymetazoline Blood volume Mucous membrane of nose Nose α1 adrenergic receptor Acoustic rhinometry Vasomotor Rhinitis Physiology (medical) otorhinolaryngologic diseases medicine Humans Vascular disease business.industry Airway Resistance Middle Aged respiratory system medicine.disease Elasticity Compliance (physiology) Nasal Decongestants Nasal Mucosa Rhinitis Vasomotor Anesthesia Female business medicine.drug |
| Zdroj: | Journal of Applied Physiology. 100:107-111 |
| ISSN: | 1522-1601 8750-7587 |
| DOI: | 10.1152/japplphysiol.00575.2005 |
| Popis: | Nasal compliance is a measure related to the blood volume in the nasal mucosa. The objective of this study was to better understand the vascular response in vasomotor rhinitis by measuring nasal cross-sectional area and nasal compliance before and after mucosal decongestion in 10 patients with vasomotor rhinitis compared with 10 healthy subjects. Nasal compliance was inferred by measuring nasal area by acoustic rhinometry at pressures ranging from atmospheric pressure to a negative pressure of −10 cmH2O. Mucosal decongestion was obtained with one puff per nostril of 0.05% oxymetazoline. At atmospheric pressure, nasal cross-sectional areas were similar in the vasomotor rhinitis group and the healthy subject group. Mucosal decongestion did not induce any decrease of nasal compliance in patients with vasomotor rhinitis in contrast with healthy subjects. Our results support the hypothesis, already proposed, of an autonomic dysfunction based on a paradoxical response of the nasal mucosa in vasomotor rhinitis. Moreover, the clearly different behavior between healthy subjects and vasomotor rhinitis subjects suggests that nasal compliance measurement may therefore represent a potential line of research to develop a diagnostic tool for vasomotor rhinitis, which remains a diagnosis of exclusion. |
| Databáze: | OpenAIRE |
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