Effect of an antiestrogen on the testicular response to acute and chronic administration of hCG in normal and hypogonadotropic hypogonadic men: tamoxifen and testicular response to hCG
| Autor: | L. Fiszlejder, S. Aszpis, Oscar Levalle, María O. Suescun, Ricardo S. Calandra, A. Guitelman, Eduardo H. Charreau |
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| Rok vydání: | 1991 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty Urology medicine.medical_treatment Chorionic Gonadotropin Andrology Basal (phylogenetics) Endocrinology Sex hormone-binding globulin Desensitization (telecommunications) Hypogonadotropic hypogonadism Internal medicine Sex Hormone-Binding Globulin medicine Hydroxyprogesterones Humans Testosterone reproductive and urinary physiology Chemotherapy Leydig cell biology Estradiol urogenital system business.industry 17-alpha-Hydroxyprogesterone Hypogonadism General Medicine medicine.disease Antiestrogen Tamoxifen medicine.anatomical_structure biology.protein business hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Andrologia. 23(2) |
| ISSN: | 0303-4569 |
| Popis: | The effect of the antiestrogen tamoxifen (Tx) on the acute and chronic hCG administration was evaluated in patients with hypogonadotropic hypogonadism (HH) and in normal men. An hCG test (5000 IU hCG) was performed before, after two months of hCG administration (2000 IU hCG three times weekly) and after two months of hCG + Tx (2000 IU hCG three times weekly plus 20 mg/day of tamoxifen). Blood samples were obtained before and following 24 and 72 h of every test to determine T, E, 17OHP and SHBG. T increased only in HH with both treatments (X +/- SEM: Basal: 97.9 +/- 19.7; hCG: 237.7 +/- 43.2; hCG +/- Tx: 204.7 +/- 10.7 ng/100 ml). 17OHP rose with hCG alone, but not with hCG + Tx in both groups. E, SHBG and 17OHP/T ratio did not change after treatments. hCG tests: E increased 24 h following hCG administration in every test. The ratio 17OHP/T rose at 24 h in the first and second test but in the third test it did not change. These results support the role of E in the acute hCG-induced Leydig cell desensitization. However, the association of Tx does not improve T serum levels, suggesting that E might not be the unique factor involved in the mechanisms for testicular desensitization. |
| Databáze: | OpenAIRE |
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