Glutathione Peroxidase 1 C593T Polymorphism Is Associated with Lobar Intracerebral Hemorrhage
| Autor: | Dorota Wloch, Agnieszka Slowik, Tomasz Dziedzic, Roman Pułyk, Andrzej Szczudlik, Joanna Pera |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Male
GPX1 Pathology medicine.medical_specialty Genotype medicine.disease_cause White People Cohort Studies Glutathione Peroxidase GPX1 Humans Medicine Aged Cerebral Hemorrhage Aged 80 and over Intracerebral hemorrhage chemistry.chemical_classification Glutathione Peroxidase Polymorphism Genetic business.industry Glutathione peroxidase Case-control study Middle Aged medicine.disease Pathophysiology Logistic Models Neurology chemistry Case-Control Studies Female Poland Neurology (clinical) Vascular pathology Genetic risk factor Cardiology and Cardiovascular Medicine business Oxidative stress |
| Zdroj: | Cerebrovascular Diseases. 25:445-449 |
| ISSN: | 1421-9786 1015-9770 |
| DOI: | 10.1159/000126918 |
| Popis: | Background: Oxidative stress plays an important role in vascular pathology and contributes to the pathophysiology of primary intracerebral hemorrhage (PICH). Glutathione peroxidase 1 (GPX1) is a key enzyme of the antioxidant system. Here, we investigated whether a functional C593T polymorphism of GPX1 gene is associated with PICH in a Polish population. Methods: Genotyping was performed in 192 PICH patients and 197 unrelated controls matched for age and sex. All were of Caucasian origin. The C593T GPX1 polymorphism was investigated using the polymerase chain reaction/restriction fragment length polymorphism method. Results: Multivariable logistic regression analysis revealed a significant association between genotypes containing the T allele and the entire PICH group (OR = 1.53; 95% CI = 1.02–2.29) and lobar PICH (OR = 2.36; 95% CI = 1.31–4.26) but not nonlobar PICH (OR = 1.19; 95% CI = 0.75–1.89). Conclusions: We found a positive association between the studied GPX1 polymorphism and lobar PICH in a Polish population. |
| Databáze: | OpenAIRE |
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