Exposure to Environmental Pollutants and Their Association with Biomarkers of Aging: A Multipollutant Approach

Autor: Dries S. Martens, Adrian Covaci, Annette Vriens, Vera Nelen, Elly Den Hond, Sam De Craemer, Michelle Plusquin, Thomas Schettgen, Greet Schoeters, Bram G. Janssen, Tim S. Nawrot, Stefaan De Henauw, Willy Baeyens, Liesbeth Bruckers, Ilse Loots
Přispěvatelé: Vriendenkring VUB, Analytical, Environmental & Geo-Chemistry, Chemistry, Biology
Rok vydání: 2019
Předmět:
Zdroj: Environmental science and technology
ISSN: 1520-5851
0013-936X
DOI: 10.1021/acs.est.8b07141
Popis: Mitochondria] DNA (mtDNA) content and telomere length are putative aging biomarkers and are sensitive to environmental stressors, including pollutants. Our objective was to identify, from a set of environmental exposures, which exposure is associated with leukocyte mtDNA content and telomere length in adults. This study includes 175 adults from 50 to 65 years old from the cross-sectional Flemish Environment and Health study, of whom leukocyte telomere length and mtDNA content were determined using qPCR. The levels of exposure of seven metals, 11 organohalogens, and four perfluorinated compounds (PFHxS, PFNA, PFOA, PFOS) were measured. We performed sparse partial least-squares regression analyses followed by ordinary least-squares regression to assess the multipollutant associations. While accounting for possible confounders and coexposures, we identified that urinary cadmium (6.52%, 95% confidence interval, 1.06, 12.28), serum hexachlorobenzene (2.89%, 018, 5.68), and perfluorooctanesulfonic acid (11.38%, 5.97, 17.08) exposure were positively associated (p < 0.05) with mtDNA content, while urinary copper (-9.88%, -14.82, -4.66) and serum perfluorohexanesulfonic acid (-4.75%, -8.79, -0.54) exposure were inversely associated with mtDNA content. Urinary antimony (2.69%, 0.45, 4.99) and mercury (1.91%, 0.42, 3.43) exposure were positively associated with leukocyte telomere length, while urinary copper (-3.52%, -6.60, -0.34) and serum perfluorooctanesulfonic acid (-3.64%, -6.60, -0.60) showed an inverse association. Our findings support the hypothesis that environmental pollutants interact with molecular hallmarks of aging.
Databáze: OpenAIRE
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