Exposure to Environmental Pollutants and Their Association with Biomarkers of Aging: A Multipollutant Approach
Autor: | Dries S. Martens, Adrian Covaci, Annette Vriens, Vera Nelen, Elly Den Hond, Sam De Craemer, Michelle Plusquin, Thomas Schettgen, Greet Schoeters, Bram G. Janssen, Tim S. Nawrot, Stefaan De Henauw, Willy Baeyens, Liesbeth Bruckers, Ilse Loots |
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Přispěvatelé: | Vriendenkring VUB, Analytical, Environmental & Geo-Chemistry, Chemistry, Biology |
Rok vydání: | 2019 |
Předmět: |
Adult
Perfluorooctanesulfonic acid Physiology Urine 010501 environmental sciences DNA Mitochondrial 01 natural sciences chemistry.chemical_compound Biomarkers of aging Humans Environmental Chemistry Biology Aged 0105 earth and related environmental sciences Pollutant Fluorocarbons Confounding Environmental Exposure General Chemistry Environmental exposure Hexachlorobenzene Middle Aged Confidence interval 3. Good health Chemistry Cross-Sectional Studies chemistry 13. Climate action Environmental Pollutants Biomarkers |
Zdroj: | Environmental science and technology |
ISSN: | 1520-5851 0013-936X |
DOI: | 10.1021/acs.est.8b07141 |
Popis: | Mitochondria] DNA (mtDNA) content and telomere length are putative aging biomarkers and are sensitive to environmental stressors, including pollutants. Our objective was to identify, from a set of environmental exposures, which exposure is associated with leukocyte mtDNA content and telomere length in adults. This study includes 175 adults from 50 to 65 years old from the cross-sectional Flemish Environment and Health study, of whom leukocyte telomere length and mtDNA content were determined using qPCR. The levels of exposure of seven metals, 11 organohalogens, and four perfluorinated compounds (PFHxS, PFNA, PFOA, PFOS) were measured. We performed sparse partial least-squares regression analyses followed by ordinary least-squares regression to assess the multipollutant associations. While accounting for possible confounders and coexposures, we identified that urinary cadmium (6.52%, 95% confidence interval, 1.06, 12.28), serum hexachlorobenzene (2.89%, 018, 5.68), and perfluorooctanesulfonic acid (11.38%, 5.97, 17.08) exposure were positively associated (p < 0.05) with mtDNA content, while urinary copper (-9.88%, -14.82, -4.66) and serum perfluorohexanesulfonic acid (-4.75%, -8.79, -0.54) exposure were inversely associated with mtDNA content. Urinary antimony (2.69%, 0.45, 4.99) and mercury (1.91%, 0.42, 3.43) exposure were positively associated with leukocyte telomere length, while urinary copper (-3.52%, -6.60, -0.34) and serum perfluorooctanesulfonic acid (-3.64%, -6.60, -0.60) showed an inverse association. Our findings support the hypothesis that environmental pollutants interact with molecular hallmarks of aging. |
Databáze: | OpenAIRE |
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