A resorbable hyaluronic acid hydrogel to prevent adhesion in porcine model under laparotomy pelvic surgery
| Autor: | Chang-Cheng Wu, Chung-Chih Tseng, Pei-Chin Chen, Yu-Wen Hung, Yen-Po Chen, Zhi-Hong Wen, Chi-Yu Yang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Swine medicine.medical_treatment Biomedical Engineering Biophysics Adhesion (medicine) Tissue Adhesions Bioengineering Biomaterials 03 medical and health sciences chemistry.chemical_compound Postoperative Complications 0302 clinical medicine Laparotomy Hyaluronic acid medicine Animals Hyaluronic Acid Pelvic surgery 030219 obstetrics & reproductive medicine business.industry Hydrogels General Medicine medicine.disease Surgery chemistry 030220 oncology & carcinogenesis Female business TP248.13-248.65 Biotechnology |
| Zdroj: | Journal of Applied Biomaterials & Functional Materials, Vol 19 (2021) |
| ISSN: | 2280-8000 |
| Popis: | Surgical post-operative adhesions can lead to serious clinical complications. Barrier agent is the broad usage for the prevention of post-operative adhesions. This study aimed to evaluate the reducing adhesion efficacy of non-animal hyaluronic acid (HA) hydrogel in pigs undergoing conventional laparotomy pelvic surgery. HA hydrogel was applied to eighteen female pigs who underwent conventional laparotomy. The adhesion degrees and histopathology were evaluated in bilateral uterine horns as well as peritoneal sidewall excision. In the present study, all animals survived and had no complications after the surgery. The histopathological observations were demonstrated that HA obviously improved laparotomy pelvic surgery-induced adhesion in peritoneal sidewall and uterine horn. The anastomotic healing score of injury + HA group was significantly lower than the injury alone group. We conclude HA hydrogel can attenuate the post-operative adhesions in porcine. |
| Databáze: | OpenAIRE |
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