Neurotrophin-3: a neurotrophic factor related to NGF and BDNF

Autor:	P C, Maisonpierre, L, Belluscio, S, Squinto, N Y, Ip, M E, Furth, R M, Lindsay, G D, Yancopoulos
Rok vydání:	1990
Předmět:	Neurons Multidisciplinary Base Sequence Brain-Derived Neurotrophic Factor Molecular Sequence Data Restriction Mapping Nerve Tissue Proteins DNA Polymerase Chain Reaction Rats Mice Sequence Homology Nucleic Acid Animals Amino Acid Sequence Nerve Growth Factors Cloning Molecular Cells Cultured
Zdroj:	Science. 247:1446-1451
ISSN:	1095-9203 0036-8075
Popis:	The development and maintenance of the nervous system depends on proteins known as neurotrophic factors. Although the prototypical neurotrophic factor, nerve growth factor (NGF), has been intensively studied for decades, the discovery and characterization of additional such factors has been impeded by their low abundance. Sequence homologies between NGF and the recently cloned brain-derived neurotrophic factor (BDNF) were used to design a strategy that has now resulted in the cloning of a gene encoding a novel neurotrophic factor, termed neurotrophin-3 (NT-3). The distribution of NT-3 messenger RNA and its biological activity on a variety of neuronal populations clearly distinguish NT-3 from NGF and BDNF, and provide compelling evidence that NT-3 is an authentic neurotrophic factor that has its own characteristic role in vivo.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eded2059ea0fb2dbc6fa96f5e0df0c59 https://doi.org/10.1126/science.247.4949.1446 Zobrazit plný text záznamu Plný text ve formátu PDF