The Cat’s in the Bag: Despite Limited Cat-to-Cat Severe Acute Respiratory Syndrome Coronavirus 2 Transmission, One Health Surveillance Efforts Are Needed
| Autor: | Meghan F. Davis, Gabriel K. Innes |
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| Rok vydání: | 2021 |
| Předmět: |
Male
2019-20 coronavirus outbreak Coronavirus disease 2019 (COVID-19) viruses Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) coronavirus medicine.disease_cause susceptibility Cell Line Chlorocebus aethiops Major Article Animals Humans transmissibility Immunology and Allergy Medicine One Health Amino Acids Vero Cells Coronavirus SARS-CoV-2 business.industry Transmission (medicine) Infectious disease transmission pathogenesis fungi cats virus diseases COVID-19 infectious disease transmission Virology Editorial AcademicSubjects/MED00290 Infectious Diseases Female Angiotensin-Converting Enzyme 2 business |
| Zdroj: | The Journal of Infectious Diseases |
| ISSN: | 1537-6613 0022-1899 |
| Popis: | Domestic cats, an important companion animal, can be infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). This has aroused concern regarding the ability of domestic cats to spread the virus that causes coronavirus disease 2019. We systematically demonstrated the pathogenesis and transmissibility of SARS-CoV-2 in cats. Serial passaging of the virus between cats dramatically attenuated the viral transmissibility, likely owing to variations of the amino acids in the receptor-binding domain sites of angiotensin-converting enzyme 2 between humans and cats. These findings provide insight into the transmissibility of SARS-CoV-2 in cats and provide information for protecting the health of humans and cats. Article Summary Line: Domestic cats are susceptible to SARS-CoV-2 and have attenuated transmissibility after serial passaging. |
| Databáze: | OpenAIRE |
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