Association between subclinical malaria infection and inflammatory host response in a pre-elimination setting

Autor: Peto, Thomas, Tripura, R, Lee, Sue, Althaus, T, Dunachie, Susanna, Nguon, C, Dhorda, Mehul, Promnarate, C, Chalk, Jeremy, Imwong, M, von Seidlein, Lorenz, Day, Nicholas, Dondorp, Adrianus, White, Nicholas, Lubell, Yoel, Luty, AJF
Přispěvatelé: Luty, A
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Male
Plasmodium
Physiology
Fevers
lcsh:Medicine
Parasitemia
Pathology and Laboratory Medicine
Polymerase Chain Reaction
0302 clinical medicine
Interquartile range
Medicine and Health Sciences
030212 general & internal medicine
Malaria
Falciparum
Child
lcsh:Science
Asymptomatic Infections
Immune Response
Subclinical infection
Protozoans
Multidisciplinary
Malarial Parasites
Hematology
Body Fluids
3. Good health
C-Reactive Protein
Blood
Infectious Diseases
Child
Preschool
Biomarker (medicine)
Female
Anatomy
medicine.symptom
Cambodia
Research Article
Adult
Adolescent
Infectious Disease Control
Plasmodium falciparum
Immunology
030231 tropical medicine
Inflammation
Biology
Asymptomatic
Blood Plasma
03 medical and health sciences
Signs and Symptoms
Diagnostic Medicine
Immunity
Parasite Groups
parasitic diseases
Malaria
Vivax
Parasitic Diseases
medicine
Humans
lcsh:R
Organisms
Infant
Biology and Life Sciences
Odds ratio
Tropical Diseases
medicine.disease
Parasitic Protozoans
Malaria
Case-Control Studies
Parasitology
lcsh:Q
Plasmodium vivax
Apicomplexa
Zdroj: PLoS ONE, Vol 11, Iss 7, p e0158656 (2016)
PLoS ONE
Popis: Background Subclinical infections in endemic areas of Southeast Asia sustain malaria transmission. These asymptomatic infections might sustain immunity against clinical malaria and have been considered benign for the host, but if they are associated with chronic low-grade inflammation this could be harmful. We conducted a case-control study to explore the association between subclinical malaria and C-reactive protein (CRP), an established biomarker of inflammation. Methods Blood samples from asymptomatic villagers in Pailin, Western Cambodia were tested for malaria by high-volume ultra-sensitive polymerase chain reaction (uPCR) to determine the Plasmodium species. Plasma CRP concentration was measured in 328 individuals with parasitaemia (cases) and compared with: i) the same individual’s value at the first time point when they had no detectable parasites (n = 282); and ii) age- sex- and village-matched controls (n = 328) free of Plasmodium infection. Plasma CRP concentrations were compared against thresholds of 3mg/L and 10mg/L. Subgroup analysis was carried out for cases with P vivax and P falciparum mono-infections. Results Median plasma CRP level for all samples was 0.59mg/L (interquartile range: 0.24–1.64mg/L). CRP concentrations were higher in parasitaemic individuals compared with same-person-controls (p = 0.050); and matched-controls (p = 0.025). 4.9% of samples had CRP concentrations above 10mg/L and 14.6% were above 3mg/L. Cases were more likely to have plasma CRP concentrations above these thresholds than age/sex matched controls, odds ratio 3.5 (95%CI 1.5–9.8) and 1.8 (95%CI 1.1–2.9), respectively. Amongst cases, parasite density and CRP were positively correlated (p
Databáze: OpenAIRE
Externí odkaz: