A second locus for Aicardi-Goutieres syndrome at chromosome 13q14-21
| Autor: | Lieven Lagae, Isabelle Desguerre, D. Cau, Didier Lacombe, Pierre Lebon, Andrew P. Jackson, B.C.J. Hamel, J.H.L.M. van Bokhoven, Uta Tacke, Cyril Goizet, Christopher D. Rittey, L.J. Highet, Amparo Sanchis, Yanick J. Crow, N. Mathieu, H.G. Brunner, Marie-Laure Moutard, M.S. van der Knaap, Y.A. Oade, Manir Ali, Mary D. King, Dhavendra Kumar |
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| Přispěvatelé: | Pediatric surgery |
| Rok vydání: | 2006 |
| Předmět: |
Male
Genetics and epigenetic pathways of disease [NCMLS 6] Genotype Genetic Linkage Short Report Alpha interferon Locus (genetics) Genes Recessive Consanguinity Lymphocytosis Biology Aicardi syndrome Genomic disorders and inherited multi-system disorders [IGMD 3] Cohort Studies Basal Ganglia Diseases Genetic linkage Genetics medicine Humans Genotyping Genetics (clinical) Chromosomes Human Pair 13 Genetic heterogeneity Infant Newborn Calcinosis Chromosome Mapping Infant Syndrome medicine.disease Genetic defects of metabolism [UMCN 5.1] Aicardi–Goutières syndrome Female Functional Neurogenomics [DCN 2] |
| Zdroj: | Journal of Medical Genetics, 43, 444-50 Journal of Medical Genetics, 43, 5, pp. 444-50 Journal of Medical Genetics, 43(5), 444-450. BMJ Publishing Group Ali, M, Highet, L J, Lacombe, D, Goizet, C, King, M D, Tacke, U, Van Der Knaap, M S, Lagae, L, Rittey, C, Brunner, H G, Van Bokhoven, H, Hamel, B, Oade, Y A, Sanchis, A, Desguerre, I, Cau, D, Mathieu, N, Moutard, M L, Lebon, P, Kumar, D, Jackson, A P & Crow, Y J 2006, ' A second locus for Aicardi-Goutières syndrome at chromosome 13q14-21 ', Journal of Medical Genetics, vol. 43, no. 5, pp. 444-450 . https://doi.org/10.1136/jmg.2005.031880 |
| ISSN: | 0022-2593 |
| DOI: | 10.1136/jmg.2005.031880 |
| Popis: | Contains fulltext : 51263.pdf (Publisher’s version ) (Closed access) BACKGROUND: Aicardi-Goutieres syndrome (AGS) is an autosomal recessive, early onset encephalopathy characterised by calcification of the basal ganglia, chronic cerebrospinal fluid lymphocytosis, and negative serological investigations for common prenatal infections. AGS may result from a perturbation of interferon alpha metabolism. The disorder is genetically heterogeneous with approximately 50% of families mapping to the first known locus at 3p21 (AGS1). METHODS: A genome-wide scan was performed in 10 families with a clinical diagnosis of AGS in whom linkage to AGS1 had been excluded. Higher density genotyping in regions of interest was also undertaken using the 10 mapping pedigrees and seven additional AGS families. RESULTS: Our results demonstrate significant linkage to a second AGS locus (AGS2) at chromosome 13q14-21 with a maximum multipoint heterogeneity logarithm of the odds (LOD) score of 5.75 at D13S768. The AGS2 locus lies within a 4.7 cM region as defined by a 1 LOD-unit support interval. CONCLUSIONS: We have identified a second AGS disease locus and at least one further locus. As in a number of other conditions, genetic heterogeneity represents a significant obstacle to gene identification in AGS. The localisation of AGS2 represents an important step in this process. |
| Databáze: | OpenAIRE |
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