SIG‐1273 protects skin against urban air pollution and when formulated in AgeIQ™ Night Cream anti‐aging benefits clinically demonstrated
| Autor: | C. Webb, Jeffry B. Stock, Joel S. Gordon, Maxwell Stock, Kristen L. Huber, Wendi Armbrister, José R. Fernández, Michael Voronkov, Eduardo Perez, J. Healy, Karl Rouzard, Masanori Tamura |
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| Rok vydání: | 2018 |
| Předmět: |
Active ingredient
Mts assay business.industry medicine.drug_class Skin exposure Dermatology Pharmacology Ascorbic acid Anti-inflammatory Skin Aging 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Cell toxicity 030220 oncology & carcinogenesis Toxicity Medicine business |
| Zdroj: | Journal of Cosmetic Dermatology. 18:1366-1371 |
| ISSN: | 1473-2165 1473-2130 |
| DOI: | 10.1111/jocd.12825 |
| Popis: | Background SIG-1273 is a novel cosmetic active that provides a broad spectrum of benefits to the skin. Considering the chronic skin exposure to pollution in urban areas, we sought to determine if SIG-1273 could provide additional protection against skin aging by inhibiting pollutant-induced cytotoxicity and inflammation. Objective Determine if SIG-1273 possesses antipollution properties in vitro and evaluate the potential anti-aging benefits of Age IQ™ Night Cream clinically in human subjects. Methods In vitro studies utilizing normal human epidermal keratinocytes (NHEKs), were co-treated with urban dust (SRM 1649b) and SIG-1273 (toxicity protection measured by MTS assay). A water-soluble fraction of urban dust (UD-WS) induces pro-inflammatory cytokine release (IL-8) from NHEKs (measured via ELISA). An 8-week, 37-subject clinical trial was performed with 0.05% SIG-1273 formulated in Age IQ™ Night Cream and applied topically to assess its potential to reduce the appearance of aging. Results In vitro studies using NHEKs demonstrate SIG-1273 protects against urban dust-induced cell toxicity, reducing cell death by 66% and concentration dependently inhibits UD-WS-induced IL-8 production (IC50 = 20 nmol/L), outperforming niacinamide, ascorbic acid, and α-tocopherol, commonly used actives in antipollution skin-care products. Clinical assessment of Age IQ™ Night Cream shows it is effective in improving the appearance of facial skin aging including fine lines and wrinkles, skin texture, skin clarity/brightness, and firmness/elasticity. Conclusions SIG-1273, is demonstrated here for the first time to possess antipollution properties. Included as a key active ingredient in Age IQ™ Night Cream, this novel topical formulation provides benefits to individuals with aging skin. |
| Databáze: | OpenAIRE |
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