Hepatosplenic gammadelta T-cell lymphoma with ring chromosome 7, an isochromosome 7q equivalent clonal chromosomal aberration
| Autor: | Laszlo Bereczki, Hajnalka Andrikovics, Eniko Bagdi, László Gopcsa, Attila Tordai, Júlia Tamáska, László Krenács, Gabriella Halm, András Kozma, Emma Ádám |
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| Rok vydání: | 2006 |
| Předmět: |
Pathology
medicine.medical_specialty Ring chromosome Isochromosome Aggressive lymphoma Biology Trisomy 8 Lymphoma T-Cell Polymerase Chain Reaction Pathology and Forensic Medicine Immunophenotyping Fatal Outcome Bone Marrow hemic and lymphatic diseases Antineoplastic Combined Chemotherapy Protocols medicine T-cell lymphoma Humans Molecular Biology In Situ Hybridization Fluorescence Chromosome Aberrations Gene Rearrangement gamma-Chain T-Cell Antigen Receptor Splenic Neoplasms Liver Neoplasms Spectral Karyotyping Cytogenetics Karyotype Cell Biology General Medicine Gene rearrangement DNA Neoplasm Middle Aged medicine.disease Clone Cells Cancer research Female Chromosomes Human Pair 7 |
| Zdroj: | Virchows Archiv : an international journal of pathology. 449(4) |
| ISSN: | 0945-6317 |
| Popis: | Hepatosplenic T-cell lymphoma is a rare, clinically aggressive lymphoma. Most cases represent a neoplasm of mature non-activated gammadelta T cells. Isochromosome 7q i(7)(q10) is thought to be the primary cytogenetic abnormality of this disease. In this paper, we describe a hepatosplenic gammadelta T-cell lymphoma case, with clonal ring chromosome 7 exemplifying an isochromosome 7q equivalent clonal aberration. A 62-year-old female patient presented with thrombocytopenia, isolated hepatosplenomegaly, and extremely high levels of LDH. Bone marrow work-up demonstrated a sinusoidal cytotoxic T-cell infiltrate with blastic features, while molecular studies verified monoclonal rearrangement for both TCR gamma and TCR delta genes. Cytogenetics revealed clonal abnormalities including ring chromosome 7, trisomy 8, and der(19), while FISH analysis detected 7q amplification with partial deletion of 7p in ring chromosome 7. To the best of our knowledge, this is the first reported T-cell lymphoma case with ring chromosome 7. |
| Databáze: | OpenAIRE |
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