COMMD5 Inhibits Malignant Behavior of Renal Cancer Cells
| Autor: | Jin Ikeda, Hiroyuki Matsuda, Masayoshi Soma, Yukimoto Ishii, Kenya Yamaguchi, Maiko Ogasawara, Morito Endo, Yoshikazu Masuhiro, Satoru Takahashi, Noboru Fukuda, Pavel Hamet, Johanne Tremblay |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
Cancer Research Carcinogenesis Endocytic cycle urologic and male genital diseases medicine.disease_cause Cancer stem cell Renal cell carcinoma Humans Medicine Neoplasm Invasiveness Epidermal growth factor receptor RNA Small Interfering Carcinoma Renal Cell Adaptor Proteins Signal Transducing Cell Proliferation biology business.industry Nuclear Proteins Cancer General Medicine Prognosis medicine.disease Phenotype Kidney Neoplasms Oncology Cancer cell Disease Progression Cancer research biology.protein Female business |
| Zdroj: | Anticancer Research. 41:2805-2815 |
| ISSN: | 1791-7530 0250-7005 |
| DOI: | 10.21873/anticanres.15061 |
| Popis: | Background/aim Copper metabolism MURR1 domain-containing 5 (COMMD5) is mainly expressed in renal tubules (RTs), where it facilitates re-differentiation of injured RTs. We reported that COMMD5 regulates the expression of epidermal growth factor receptor by participating in its endocytic membrane trafficking, thus inhibiting tumor growth. Here we aimed to determine the role of COMMD5 in malignant phenotypes of renal cell carcinoma (RCC). Materials and methods The associations between COMMD5 levels in RTs adjacent to RCC tumors in patients and their clinicopathologic characteristics were evaluated, and the effects of COMMD5 on cancer stemness in RCC cells were investigated. Results Low COMMD5 levels in RTs correlated with high tumorigenesis and poor patient outcomes. COMMD5 overexpression in RCC cells reduced the proportion of cancer stem cell-like cells and their malignant phenotypes, including proliferation, invasion and sphere formation. Secreted COMMD5 from RT cells also reduced malignant phenotypes. Conclusion COMMD5 might suppress malignant phenotypes of RCC, thus inhibiting tumor development and improving patient prognosis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|