Serum fluoxetine and norfluoxetine concentrations and antidepressant response
| Autor: | Michael J. Garvey, Michael W. Kelly, Paul J. Perry, Sheldon G. Holstad |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Adult
Male medicine.medical_specialty Metabolite Pharmacology High-performance liquid chromatography chemistry.chemical_compound Random Allocation Pharmacokinetics Double-Blind Method Fluoxetine medicine Humans Pharmacology (medical) Depressive Disorder Dose-Response Relationship Drug business.industry Hamilton Rating Scale for Depression Middle Aged Surgery Dose–response relationship chemistry Clinical Global Impression Antidepressant Female business medicine.drug Half-Life |
| Zdroj: | Therapeutic drug monitoring. 11(2) |
| ISSN: | 0163-4356 |
| Popis: | A high-performance liquid chromatography assay for fluoxetine and its major metabolite, norfluoxetine, was established. Serum concentrations of the two were measured in 13 depressed outpatients following a 6-week trial of the drug. No significant correlations were obvious between clinical improvement as measured by the Hamilton Rating Scale for Depression and the Clinical Global Impression scores and the serum concentrations of fluoxetine and its major metabolite, norfluoxetine, according to these initial pilot data. |
| Databáze: | OpenAIRE |
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