Synthesis optimization of 2-(4-N-[11C]methylaminophenyl)-6-hydroxybenzothiazole ([11C]PIB), ?-amyloid PET imaging tracer for Alzheimer's disease diagnosis
| Autor: | A.Coliva a, C.Monterisi b, A.Apollaro b, D.Gatti c, M.Penso d, L.Gianolli c, D.Perani a, b, M.C. Gilardi b, c, A.Carpinelli b |
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| Přispěvatelé: | Coliva, A., Monterisi, C., Apollaro, A., Gatti, D., Penso, M., Gianolli, L., Perani, DANIELA FELICITA L., Gilardi, M. C., Carpinelli, A., Coliva, A, Monterisi, C, Apollaro, A, Gatti, D, Penso, M, Gianolli, L, Perani, D, Gilardi, M, Carpinelli, A |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Quality Control
Amyloid ?-amyloid High-performance liquid chromatography chemistry.chemical_compound Alzheimer Disease medicine Humans Benzothiazoles Carbon Radioisotopes [11C]PIB Acetonitrile Amyloid beta-Peptides Aniline Compounds Radiation Ethanol Chromatography β-amyloid Elution Radiosynthesis Methylation Alzheimer's disease medicine.disease Alzheimer's disease Cyclotron [11C]MeOTf [11C]PIB β-amyloid Thiazoles chemistry Biochemistry [11C]MeOTf Positron-Emission Tomography Cyclotron Radiopharmaceuticals |
| Zdroj: | Applied radiation and isotopes 105 (2015): 66–71. doi:10.1016/j.apradiso.2015.07.003 info:cnr-pdr/source/autori:A.Coliva a, C.Monterisi b, A.Apollaro b, D.Gatti c, M.Penso d, L.Gianolli c, D.Perani a,b, M.C. Gilardi b,c, A.Carpinelli b,c/titolo:Synthesis optimization of 2-(4-N-[11C]methylaminophenyl)-6-hydroxybenzothiazole ([11C]PIB), ?-amyloid PET imaging tracer for Alzheimer's disease diagnosis./doi:10.1016%2Fj.apradiso.2015.07.003/rivista:Applied radiation and isotopes/anno:2015/pagina_da:66/pagina_a:71/intervallo_pagine:66–71/volume:105 |
| DOI: | 10.1016/j.apradiso.2015.07.003 |
| Popis: | [11C]PIB is the most used amyloid plaques-specific positron-emitting radiotracers. The radiosynthesis of this compound, carried out by methylation of its precursor with [11C]methyl triflate in 2-butanone, has been improved optimizing the initial concentration and the purification method. Two HPLC methods were compared: good radiochemical yields, specific activities, and chemical purity above 98% were achieved by using as eluant acetonitrile/citrate and formulation in 10% ethanol. |
| Databáze: | OpenAIRE |
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