Spatial indices of repolarization correlate with non-ST elevation myocardial ischemia in patients with chest pain
| Autor: | Clifton W. Callaway, Prem Soman, Salah S. Al-Zaiti, Jan Nemec, Robert L. Lux, Ervin Sejdic |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Chest Pain medicine.medical_specialty Benign early repolarization Stress testing Biomedical Engineering Ischemia 030204 cardiovascular system & hematology Chest pain 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans ST segment Repolarization cardiovascular diseases Non-ST Elevated Myocardial Infarction Cardiac imaging Aged Demography Aged 80 and over Tomography Emission-Computed Single-Photon business.industry ST elevation Middle Aged medicine.disease Computer Science Applications Anesthesia Multivariate Analysis Electrocardiography Ambulatory Cardiology Female medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Medical & Biological Engineering & Computing. 56:1-12 |
| ISSN: | 1741-0444 0140-0118 |
| DOI: | 10.1007/s11517-017-1659-1 |
| Popis: | Mild-to-moderate ischemia does not result in ST segment elevation on the electrocardiogram (ECG), but rather non-specific changes in the T wave, which are frequently labeled as non-diagnostic for ischemia. Robust methods to quantify such T wave heterogeneity can have immediate clinical applications. We sought to evaluate the effects of spontaneous ischemia on the evolution of spatial T wave changes, based on the eigenvalues of the spatial correlation matrix of the ECG, in patients undergoing nuclear cardiac imaging for evaluating intermittent chest pain. We computed T wave complexity (TWC), the ratio of the second to the first eigenvalue of repolarization, from 5-min baseline and 5-min peak-stress Holter ECG recordings. Our sample included 30 males and 20 females aged 63 ± 11 years. Compared to baseline, significant changes in TWC were only seen in patients with ischemia (n = 10) during stress testing, but not among others. The absolute changes in TWC were significantly larger in the ischemia group compared to others, with a pattern that seemed to depend on the severity or anatomic distribution of ischemia. Our results demonstrate that ischemia-induced changes in T wave morphology can be meaningfully quantified from the surface 12-lead ECG, suggesting an important opportunity for improving diagnostics in patients with chest pain. |
| Databáze: | OpenAIRE |
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