Comparing Cortical Plasticity Induced by Conventional and High-Definition 4 × 1 Ring tDCS: A Neurophysiological Study
| Autor: | Min-Fang Kuo, Preet Minhas, Hsiao-I. Kuo, Walter Paulus, Marom Bikson, Abhishek Datta, Michael A. Nitsche |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Plasticity medicine.medical_treatment Biophysics Stimulation 050105 experimental psychology lcsh:RC321-571 03 medical and health sciences 0302 clinical medicine Neuroplasticity medicine Humans 0501 psychology and cognitive sciences Electrodes lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Neurons Brain Mapping Neuronal Plasticity Transcranial direct-current stimulation High definition tDCS General Neuroscience 05 social sciences Neurophysiology Evoked Potentials Motor Electric Stimulation Transcranial magnetic stimulation medicine.anatomical_structure Motor cortex NMDA receptor Female Transcranial direct current stimulation Neurology (clinical) Primary motor cortex Psychology Neuroscience 030217 neurology & neurosurgery Human |
| Zdroj: | Brain Stimulation, Vol 6, Iss 4, Pp 644-648 (2013) |
| ISSN: | 1935-861X |
| Popis: | Background Transcranial direct current stimulation (tDCS) induces long-lasting NMDA receptor-dependent cortical plasticity via persistent subthreshold polarization of neuronal membranes. Conventional bipolar tDCS is applied with two large (35 cm 2 ) rectangular electrodes, resulting in directional modulation of neuronal excitability. Recently a newly designed 4 × 1 high-definition (HD) tDCS protocol was proposed for more focal stimulation according to the results of computational modeling. HD tDCS utilizes small disc electrodes deployed in 4 × 1 ring configuration whereby the physiological effects of the induced electric field are thought to be grossly constrained to the cortical area circumscribed by the ring. Objective We aim to compare the physiological effects of both tDCS electrode arrangements on motor cortex excitability. Methods tDCS was applied with 2 mA for 10 min. Fourteen healthy subjects participated, and motor cortex excitability was monitored by transcranial magnetic stimulation (TMS) before and after tDCS. Results Excitability enhancement following anodal and a respective reduction after cathodal stimulation occurred in both, conventional and HD tDCS. However, the plastic changes showed a more delayed peak at 30 min and longer lasting after-effects for more than 2 h after HD tDCS for both polarities, as compared to conventional tDCS. Conclusion The results show that this new electrode arrangement is efficient for the induction of neuroplasticity in the primary motor cortex. The pattern of aftereffects might be compatible with the concept of GABA-mediated surround inhibition, which should be explored in future studies directly. |
| Databáze: | OpenAIRE |
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