Serum levels of 25(OH)D are not associated with venous thromboembolism in the elderly population
| Autor: | J.-L. Carre, Andro M, Moineau Mp, Cécile Tromeur, Le Gal G, Maelenn Gouillou, Karine Lacut, Aurélien Delluc, Gentric A |
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| Přispěvatelé: | Service de Médecine Interne Gériatrique (BREST - SMIG), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Groupe d'Etude de la Thrombose de Bretagne Occidentale (GETBO), Université de Brest (UBO)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO)-Université de Brest (UBO), Département de Médecine Interne et Pneumologie [Brest] (DMIP - Brest), Service de Biochimie et Biologie Moléculaire, Centre d'Investigation Clinique (CIC - Brest), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM), École normale supérieure - Cachan (ENS Cachan), Service d'angiologie et d'hémostase (MR), Hôpital Universitaire de Genève |
| Rok vydání: | 2016 |
| Předmět: |
Male
Time Factors [SDV]Life Sciences [q-bio] Walking 030204 cardiovascular system & hematology Body Mass Index chemistry.chemical_compound 0302 clinical medicine Odds Ratio Prevalence risk factors Medicine Prospective Studies 030212 general & internal medicine Vitamin D Aged 80 and over education.field_of_study Incidence Incidence (epidemiology) Age Factors Hematology aged Female France Independent Living Seasons case-control Vitamin medicine.medical_specialty venous thromboembolism Population Risk Assessment vitamin D deficiency 03 medical and health sciences [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system Internal medicine Vitamin D and neurology Humans Obesity cardiovascular diseases education Geriatric Assessment Gynecology Chi-Square Distribution business.industry Case-control study Odds ratio Vitamin D Deficiency equipment and supplies medicine.disease Logistic Models chemistry Case-Control Studies Multivariate Analysis business Body mass index Biomarkers [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| Zdroj: | Thrombosis and Haemostasis Thrombosis and Haemostasis, Schattauer, 2015, 115 (1), pp.169-75. ⟨10.1160/TH15-02-0148⟩ |
| ISSN: | 2567-689X 0340-6245 |
| Popis: | SummaryThe prevalence of both vitamin D deficiency and venous thromboembolism (VTE) is important in the elderly. Previous studies have provided evidence for a possible association between vitamin D status and the risk of VTE. Thus, we aimed to investigate the association between vitamin D levels and VTE in the population aged 75 and over included in the EDITH case-control study. The association between vitamin D status and VTE was analysed. We also analysed the monthly and seasonal variations of VTE and vitamin D. Between May 2000 and December 2009, 340 elderly patients (mean age 81.5 years, 32 % men) with unprovoked VTE and their controls were included. The univariate and multivariate analysis found no significant association between serum levels of vitamin D and the risk of unprovoked VTE. In the unadjusted analysis, a higher BMI was statistically associated with an increased risk of VTE (OR 1.09; 95 % CI 1.05–1.13) whereas a better walking capacity and living at home were associated with a decreased rate of VTE: OR 0.57; 95 % CI 0.36–0.90 and 0.40; 95 % CI 0.25–0.66, respectively. Although not significant, more VTE events occurred during winter (p=0.09). No seasonal variations of vitamin D levels were found (p=0.11). In conclusion, in contrast with previous reports our findings suggest that vitamin D is not associated with VTE in the elderly population. |
| Databáze: | OpenAIRE |
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