Paraventricular Thalamus Activity during Motivational Conflict Highlights the Nucleus as a Potential Constituent in the Neurocircuitry of Addiction
| Autor: | Jessica S. Flannery, Ranjita Poudel, Lauren D. Hill-Bowen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
genetic structures Journal Club media_common.quotation_subject Decision Making Midline Thalamic Nuclei Motor Activity behavioral disciplines and activities Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine Thalamus Reward medicine Animals Research Articles 030304 developmental biology media_common 0303 health sciences Motivation General Neuroscience Addiction Rats Behavior Addictive medicine.anatomical_structure Incentive salience Conditioning Operant Paraventricular thalamus Cues Psychology Neuroscience Nucleus 030217 neurology & neurosurgery psychological phenomena and processes |
| Zdroj: | J Neurosci |
| Popis: | Decision-making often involves motivational conflict because of the competing demands of approach and avoidance for a common resource: behavior. This conflict must be resolved as a necessary precursor for adaptive behavior. Here we show a role for the paraventricular thalamus (PVT) in behavioral control during motivational conflict. We used Pavlovian counterconditioning in male rats to establish a conditioned stimulus (CS) as a signal for reward (or danger) and then transformed the same CS into a signal for danger (or reward). After such training, the CS controls conflicting appetitive and aversive behaviors. To assess PVT involvement in conflict, we injected an adeno-associated virus (AAV) expressing the genetically encoded Ca(2+) indicator GCaMP and used fiber photometry to record population PVT Ca(2+) signals. We show distinct profiles of responsivity across the anterior–posterior axis of PVT during conflict, including an ordinal relationship between posterior PVT CS responses and behavior strength. To study the causal role of PVT in behavioral control during conflict, we injected AAV expressing the inhibitory hM4Di DREADD and determined the effects of chemogenetic PVT inhibition on behavior. We show that chemogenetic inhibition across the anterior–posterior axis of the PVT, but not anterior or posterior PVT alone, disrupts arbitration between appetitive and aversive behaviors when they are in conflict but has no effect when these behaviors are assessed in isolation. Together, our findings identify PVT as central to behavioral control during motivational conflict. SIGNIFICANCE STATEMENT Animals, including humans, approach attractive stimuli and avoid aversive ones. However, they frequently face conflict when the demands of approach and avoidance are incompatible. Resolution of this conflict is fundamental to adaptive behavior. Here we show a role for the paraventricular thalamus, a nucleus of the dorsal midline thalamus, in the arbitration of appetitive and aversive behavior during motivational conflict. |
| Databáze: | OpenAIRE |
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