Molecular interactions within the IL-6/IL-12 cytokine/receptor superfamily
| Autor: | Dario A. A. Vignali, Lindsay L. Jones |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Genetics
biology Janus kinase 1 T-Lymphocytes medicine.medical_treatment Immunology Receptors Interleukin-12 Glycoprotein 130 Receptors Interleukin-6 Article Protein Structure Tertiary Cell biology Structure-Activity Relationship Cytokine Immune system Mutagenesis biology.protein Interleukin 12 medicine Interleukin 23 Animals Humans Protein Structure Quaternary Interleukin 6 Cytokine receptor |
| Zdroj: | Immunologic Research. 51:5-14 |
| ISSN: | 1559-0755 0257-277X |
| DOI: | 10.1007/s12026-011-8209-y |
| Popis: | Production of cytokines by immune cells in response to stimuli and the binding of cytokines to specific receptors on target cells is a central feature of the immune response. The IL-12 cytokine family is particularly influential in determining the fate of T cells and is characterized by the sharing of cytokine and receptor subunits. A thorough understanding of the molecular interactions within this family will be a key to the development of therapeutic inhibitors or enhancers of IL-12 family function. While the current structural and molecular data for IL-12 family members is limited, there is ample information on the structurally related IL-6 cytokine family. This review will summarize the current structural and mutagenesis data within the IL-12 family and will attempt to utilize similarities between the IL-6 and IL-12 families to understand molecular interactions between IL-12 family subunits and with receptor components. |
| Databáze: | OpenAIRE |
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