Phytochemical analysis of Viburnum davidii Franch. and cholinesterase inhibitory activity of its dihydrochalcones
| Autor: | Anna Maria Fabbri, Maria Teresa Volpe, Maria Francesca Cometa, Antonio Ventrone, Lamberto Tomassini, Claudio Frezza, Stefano Fortuna |
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| Rok vydání: | 2020 |
| Předmět: |
phytochemical analysis
Flavonoid adoxaceae Plant Science 01 natural sciences Biochemistry Analytical Chemistry chemistry.chemical_compound Butyrylcholinesterase Cholinesterase chemistry.chemical_classification acetylcholinesterase inhibitory activity biology Traditional medicine 010405 organic chemistry Organic Chemistry Viburnum davidii Franch dihydrochalcones butyrylcholinesterase inhibitory activity Viburnum davidii biology.organism_classification Acetylcholinesterase 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry Phytochemical biology.protein Adoxaceae Quercetin |
| DOI: | 10.6084/m9.figshare.13134957 |
| Popis: | One flavonoid (quercetin, 1) and three dihydrochalcones (6''-O-p-hydroxybenzoyl-davidioside, 2, 4'-O-methyl-davidioside, 3, and davidioside, 4) were isolated from the leaves and young branches of Viburnum davidii Franch. All the structures were identified by comparison of their spectroscopic data (NMR and MS) with those present in literature. In addition, compounds 2–4 were evaluated for their cholinesterase inhibitory (ChEI) activity, for the first time. Accordingly, compounds 2 and 4 showed significant inhibition of both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) with IC50 values equal to 36.883 and 39.274 µM, respectively for the former and 39.504 and 43.101 µM, respectively for the latter. |
| Databáze: | OpenAIRE |
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