Reduced risk of pancreatic cancer associated with asthma and nasal allergies
| Autor: | Víctor Manuel Barberá, William Greenhalf, Rita T. Lawlor, Jörg Kleeff, Luis Muñoz-Bellvís, Antoni Farré, Linda Sharp, Matthias Löhr, Francisco X. Real, Adonina Tardón, Núria Malats, Joaquim Balcells, Michael O'Rorke, L. Barneo, Bo Kong, Jan-Paul Zock, Josefina Mora, Lucas Ilzarbe, Thomas M. Gress, Ignasi Poves, PanGenEU Study Investigators, Tatjana Crnogorac-Jurcevic, Alfredo Carrato, Damian O'Driscoll, Carmen Guillén-Ponce, Liam J. Murray, José Perea, Marta Rava, Paulina Gomez-Rubio, Enrique Dominguez-Munoz, Xavier Molero, Manuel Hidalgo, P. Pelaez, Mirari Marquez, Christoph W. Michalski, Eithne Costello, Cristina Alvarez-Urturi, Aldo Scarpa |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Oncology Male medicine.medical_specialty Allergy endocrine system diseases ductal adenocarcinoma of the pancreas (PDAC) nasal allergies Lower risk 03 medical and health sciences 0302 clinical medicine nasal allergies Pancreatic cancer Internal medicine Carcinoma medicine Humans Asthma Aged business.industry Gastroenterology Case-control study Cancer Middle Aged Protective Factors medicine.disease Rhinitis Allergic digestive system diseases Europe Pancreatic Neoplasms 030104 developmental biology 030220 oncology & carcinogenesis Meta-analysis Case-Control Studies Immunology Dermatitis Allergic Contact ductal adenocarcinoma of the pancreas (PDAC) Female business Carcinoma Pancreatic Ductal |
| Zdroj: | Gut r-FISABIO. Repositorio Institucional de Producción Científica instname r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante r-FISABIO: Repositorio Institucional de Producción Científica Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) |
| ISSN: | 0017-5749 |
| Popis: | Objective Studies indicate an inverse association between ductal adenocarcinoma of the pancreas (PDAC) and nasal allergies. However, controversial findings are reported for the association with asthma. Understanding PDAC risk factors will help us to implement appropriate strategies to prevent, treat and diagnose this cancer. This study assessed and characterised the association between PDAC and asthma and corroborated existing reports regarding the association between allergies and PDAC risk. Design Information about asthma and allergies was collated from 1297 PDAC cases and 1024 controls included in the PanGenEU case-control study. Associations between PDAC and atopic diseases were studied using multilevel logistic regression analysis. Meta-analyses of association studies on these diseases and PDAC risk were performed applying random-effects model. Results Asthma was associated with lower risk of PDAC (OR 0.64, 95% CI 0.47 to 0.88), particularly long-standing asthma (>=17 years, OR 0.39, 95% CI 0.24 to 0.65). Meta-analysis of 10 case-control studies sustained our results (metaOR 0.73, 95% CI 0.59 to 0.89). Nasal allergies and related symptoms were associated with lower risk of PDAC (OR 0.66, 95% CI 0.52 to 0.83 and OR 0.59, 95% CI 0.46 to 0.77, respectively). These results were supported by a meta-analysis of nasal allergy studies (metaOR 0.6, 95% CI 0.5 to 0.72). Skin allergies were not associated with PDAC risk. Conclusions This study shows a consistent inverse association between PDAC and asthma and nasal allergies, supporting the notion that atopic diseases are associated with reduced cancer risk. These results point to the involvement of immune and/or inflammatory factors that may either foster or restrain pancreas carcinogenesis warranting further research to understand the molecular mechanisms driving this association. |
| Databáze: | OpenAIRE |
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