Tissue-specific targeting of retroviral vectors through ligand-receptor interactions
| Autor: | Noriyuki Kasahara, Yuet Wai Kan, Andrée M. Dozy |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Erythrocytes
viruses Genetic enhancement Recombinant Fusion Proteins Genetic Vectors Molecular Sequence Data Gene delivery Ligands Transfection Virus Cell Line Mice Viral Envelope Proteins Murine leukemia virus Receptors Erythropoietin Tumor Cells Cultured Animals Humans Vector (molecular biology) Erythropoietin Multidisciplinary biology Base Sequence 3T3 Cells Genetic Therapy biology.organism_classification Fusion protein Virology Erythropoietin receptor Cell culture Receptors Virus Moloney murine leukemia virus HeLa Cells |
| Zdroj: | Science (New York, N.Y.). 266(5189) |
| ISSN: | 0036-8075 |
| Popis: | The development of retroviral vectors that target specific cell types could have important implications for the design of gene therapy strategies. A chimeric protein containing the polypeptide hormone erythropoietin and part of the env protein of ecotropic Moloney murine leukemia virus was engineered into the virus. This murine virus became several times more infectious for murine cells bearing the erythropoietin receptor, and it also became infectious for human cells bearing the erythropoietin receptor. This type of tissue-specific targeting by means of ligand-receptor interactions may have broad applications to a variety of gene delivery systems. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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