Do CO2 and oxidative stress induce cancer?: a brief study about the evaluation of PON 1, CAT, CA and XO enzyme levels on head and neck cancer patients
| Autor: | M. Hakan Korkmaz, Güleser Saylam, Ender Şimşek, Murad Mutlu, Tuğba Kevser Uysal, Ömer Bayır, Beyza Ecem Öz Bedir, Ozen Ozensoy Guler, Emine Terzi |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty medicine.disease_cause chemistry.chemical_compound Internal medicine Carbonic anhydrase Drug Discovery Biomarkers Tumor medicine Humans Xanthine oxidase Carbonic Anhydrases Pharmacology chemistry.chemical_classification biology Aryldialkylphosphatase business.industry lcsh:RM1-950 Head and neck cancer catalase Paraoxonase Cancer General Medicine Carbon Dioxide Middle Aged medicine.disease Healthy Volunteers paraoxonase Oxidative Stress lcsh:Therapeutics. Pharmacology Enzyme Endocrinology chemistry Head and Neck Neoplasms Catalase biology.protein Female head and neck cancer business Oxidative stress xanthine oxidase Research Paper |
| Zdroj: | Journal of Enzyme Inhibition and Medicinal Chemistry Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 459-464 (2019) |
| ISSN: | 1475-6374 1475-6366 |
| Popis: | Head and neck cancer (HNC) is one of the most common malignancies in the world. HNC is a group of cancers that starts in the mouth, nose, throat, larynx, sinuses, or salivary glands. According to this section of the body parts; induction of cancer can be associated with CO2 and oxidative stress. The aim of this study is to assess the activities of carbonic anhydrase (CA), catalase (CAT), paraoxonase1 (PON1), and xanthine oxidase (XO) activities in 89 HNC patients and 115 healthy volunteers. Paraoxonase1 activity was found lower in HNC cancer patients. There is no statistically significant difference between patients and controls for catalase, carbonic anhydrase, and xanthine oxidase enzyme levels. According to this results, paraoxonase1 levels could be a candidate as an oxidative marker in HNC patients, but further studies are needed to investigate the other type of cancer related PON1 and the other enzyme levels. |
| Databáze: | OpenAIRE |
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