Extracellular Vesicles as Messengers in Atherosclerosis
| Autor: | Mengna Peng, Gelin Xu, Xinfeng Liu |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Myocytes Smooth Muscle Pharmaceutical Science 030204 cardiovascular system & hematology medicine.disease_cause Extracellular vesicles Extracellular Vesicles 03 medical and health sciences 0302 clinical medicine Cell Movement microRNA Genetics medicine Animals Humans Genetics (clinical) Cell Proliferation business.industry Endothelial Cells Arteries Hypoxia (medical) Atherosclerosis Plaque Atherosclerotic Microvesicles 030104 developmental biology Gene Expression Regulation Immunology Molecular Medicine medicine.symptom Cardiology and Cardiovascular Medicine business Biomarkers Oxidative stress Signal Transduction |
| Zdroj: | Journal of Cardiovascular Translational Research. 13:121-130 |
| ISSN: | 1937-5395 1937-5387 |
| Popis: | Atherosclerosis is a major cause of cardiovascular diseases. Most cells involved in atherosclerosis can shed extracellular vesicles (EVs). Both atherogenic factors, such as hypoxia and oxidative stress, and atheroprotective factors, such as laminar blood flow, can influence the production of EV shedding. EVs can carry protein, DNA, mRNA, and noncoding RNA and act as mediators or messengers for cell-to-cell communications. EVs have been proven to promote or inhibit atherogenesis under particular circumstances. Therefore, EVs might be targeted for preventing or treating atherosclerotic diseases. The level of circulating EVs has been associated with the presence, progressiveness, or severity of atherosclerosis. Therefore, EVs may be utilized as indexes for diagnosing and grading atherosclerosis. Here, we reviewed the progress concerning the involvements of EVs in atherogenesis and atheroprotection. We also discussed the potential applications of EVs in managing atherosclerotic diseases. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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