Protein Biomarkers of New-Onset Cardiovascular Disease
| Autor: | Christopher J. O'Donnell, Paul Courchesne, Pieter Muntendam, Caroline S. Fox, Martin G. Larson, Aram Adourian, Shih-Jen Hwang, Subha Subramanian, Daniel Levy, Peter Juhasz, Neal Gordon, Xiaoyan Yin |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Proteomics medicine.medical_specialty Myocardial Infarction Disease Bioinformatics Risk Assessment Mass Spectrometry Article Decision Support Techniques Risk Factors Epidemiology medicine Humans Prospective Studies Myocardial infarction Prospective cohort study Aged business.industry Incidence Systems Biology Case-control study Blood Proteins Middle Aged Prognosis medicine.disease Massachusetts Case-Control Studies Biomarker (medicine) Female Cardiology and Cardiovascular Medicine business Risk assessment Biomarkers |
| Zdroj: | Arteriosclerosis, Thrombosis, and Vascular Biology. 34:939-945 |
| ISSN: | 1524-4636 1079-5642 |
| Popis: | Objective— Incorporation of novel plasma protein biomarkers may improve current models for prediction of atherosclerotic cardiovascular disease (ASCVD) risk. Approach and Results— We used discovery mass spectrometry (MS) to determine plasma concentrations of 861 proteins in 135 myocardial infarction (MI) cases and 135 matched controls. Then, we measured 59 markers by targeted MS in 336 ASCVD case–control pairs. Associations with MI or ASCVD were tested in single-marker and multiple-marker analyses adjusted for established ASCVD risk factors. Twelve single markers from discovery MS were associated with MI incidence (at P P P P Conclusions— Proteomics profiling identified single- and multiple-marker protein panels that are associated with new-onset ASCVD and may lead to a better understanding of underlying disease mechanisms. Our findings include many novel protein biomarkers that, if externally validated, may improve risk assessment for MI and ASCVD. |
| Databáze: | OpenAIRE |
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