Correlation between the 24-h urinary angiotensinogen or aldosterone level and muscle mass: Japan shimanami health promoting program study
| Autor: | Michiya Igase, Kana Tsukuda, Masaki Mogi, Masatsugu Horiuchi, Katsuhiko Kohara, Yasuharu Tabara |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Sarcopenia medicine.medical_specialty Physiology Urinary system Angiotensinogen Health Promotion Urine 030204 cardiovascular system & hematology Healthy Aging Renin-Angiotensin System Excretion 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Japan Risk Factors Internal medicine Hand strength Electric Impedance Internal Medicine medicine Humans Muscle Skeletal Aldosterone Aged Aged 80 and over Anatomy Cross-Sectional Hand Strength business.industry Confounding Middle Aged medicine.disease Endocrinology chemistry Arterial stiffness Female Cardiology and Cardiovascular Medicine business 030217 neurology & neurosurgery |
| Zdroj: | Hypertension Research. 41:326-333 |
| ISSN: | 1348-4214 0916-9636 |
| Popis: | Our previous report indicated that sarcopenia is associated with arterial stiffness and cardiovascular death. The renin-angiotensin system (RAS) plays an important role in cardiovascular disease and its activation may be correlated with sarcopenia according to basic research. However, few clinical studies have assessed the correlation between skeletal muscle loss and RAS component concentrations in healthy subjects. The purpose of this study was to investigate the relationships between the excretion of angiotensinogen (AGT) and aldosterone (Ald) in 24-h urine samples and clinical and sarcopenic indices. A total of 344 people participated in a voluntary medical check-up program, "Anti-Aging Doc", and underwent measurement of their sarcopenia-related indices. Urine samples were collected for 24-h within 8 weeks after a medical check-up using a partition cup and a proportional sampling method. Urine AGT and Ald levels were evaluated by enzyme-linked immunosorbent assay (ELISA). After compensating for possible confounding parameters, including baPWV, the 24-h urinary excretion of AGT was independently and negatively associated with the thigh muscle cross-sectional area. On the other hand, urinary Ald excretion was not associated with sarcopenia-related indices after compensation, even though it showed a modest but significantly positive association with sarcopenic indices in single regression analysis. Urinary AGT was related to sarcopenic indices and may be involved in the pathogenesis of sarcopenia. On the other hand, urinary Ald was not related to sarcopenic indices when considering other risk factors. |
| Databáze: | OpenAIRE |
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