Comparative study between Dexmedetomidine and Ondansteron for prevention of post spinal shivering. A randomized controlled trial
| Autor: | Mohammed Awad Alsaeid Ahmed, Atef Mohamed Sayed Mahmoud, Hany Maher Salib Roushdy, Safaa Gaber Ragab, Maged Labib Bolus, Joseph Makram Botros, Abeer Shaban Goda, Hany Mahmoud Yassin |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Nausea Sedation Blood Pressure Pilot Projects Intraoperative hypothermia Placebo Anesthesia Spinal law.invention lcsh:RD78.3-87.3 Ondansetron 03 medical and health sciences Postoperative Complications 0302 clinical medicine Randomized controlled trial Heart Rate 030202 anesthesiology law medicine Humans Hypnotics and Sedatives Prospective Studies Dexmedetomidine business.industry Shivering 030208 emergency & critical care medicine Perioperative Anesthesiology and Pain Medicine lcsh:Anesthesiology Anesthesia Antiemetics Female Spinal anesthesia medicine.symptom business Research Article medicine.drug |
| Zdroj: | BMC Anesthesiology BMC Anesthesiology, Vol 18, Iss 1, Pp 1-8 (2018) |
| ISSN: | 1471-2253 |
| Popis: | Background Regional anesthesia could affect the homeostatic system functions resulting frequently in perioperative hypothermia and consequently shivering. The objective of this trial was to evaluate the efficacy of dexmedetomidine and ondansetron to reduce the incidence and severity of shivering after intrathecal blocks. Methods This randomized placebo-controlled trial included 120 patients allocated equally in three groups. All patients were anesthetized by standard intrathecal blocks for surgical procedure at lower half of the body and received one of the study drugs intravenously (IV) according to the group assignments. Group S patients (placebo) were administered saline, Group O (ondansetron) were given 8 mg ondansetron, and Group D (dexmedetomidine) were given 1 μg/kg of dexmedetomidine. Shivering incidence and scores, sedation scores, core body temperature, hemodynamic variables, and incidence of complications (nausea, vomiting, hypotension, bradycardia, over-sedation, and desaturation) were recorded. Results The incidence and 95% confidence interval (95% CI) of shivering in group S 57.5% (42.18–72.82%) was significantly higher than that of both group O 17.5% (5.73–29.27%), P |
| Databáze: | OpenAIRE |
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