Influence of Immunosuppressive Therapy on Lipoprotein(a) and Other Lipoproteins following Renal Transplantation
| Autor: | Deepak Bhatnagar, C C Doherty, Colin D. Short, Barbara Murphy, Paul N. Durrington, Mike Mackness, A F Douglas, J H Brown, Linda P. Hunt |
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| Rok vydání: | 1997 |
| Předmět: |
Adult
Male Blood lipoprotein medicine.medical_specialty Adolescent Lipoproteins Matched-Pair Analysis Prednisolone medicine.medical_treatment Gastroenterology Risk Factors Internal medicine Azathioprine medicine Humans Triglycerides Kidney transplantation Aged Kidney biology business.industry Immunosuppression General Medicine Lipoprotein(a) Middle Aged medicine.disease Kidney Transplantation Transplantation Cholesterol medicine.anatomical_structure Endocrinology Nephrology Cyclosporine biology.protein Drug Therapy Combination Female business Immunosuppressive Agents Kidney disease medicine.drug |
| Zdroj: | Nephron. 75:277-282 |
| ISSN: | 1423-0186 0028-2766 |
| Popis: | Coronary heart disease (CHD) is more common in patients with chronic renal failure and is a major cause of death after renal transplantation. Elevated serum levels of lipoprotein(a) (Lp(a)) are a known risk factor for CHD in the general population and levels have been reported to be increased in renal transplant recipients. It has been suggested that cyclosporin may elevate Lp(a) levels. We therefore measured the serum concentration of Lp(a) in 50 renal transplant recipients who were receiving cyclosporin alone as immunosuppressive therapy and 50 who were treated with azathioprine and prednisolone, but not cyclosporin. The patients attended two renal transplant centres, one where cyclosporin alone was used as immunosuppressive treatment when possible and another where many patients commenced on azathioprine and prednisolone remain on this medication rather than cyclosporin. Patients in each group were matched for age and sex, but the time since transplantation was greater in those not receiving cyclosporin. Transplant function, obesity and the underlying cause of renal disease were similar in both groups of patients. Median Lp(a) concentration in the cyclosporin monotherapy group was 32.0 (range |
| Databáze: | OpenAIRE |
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