Characterization of the Salt and Free Base of Active Pharmaceutical Ingredients Based on NMR Relaxometry Measured by Time Domain NMR

Autor:	Yuya, Chiba, Kotaro, Okada, Yoshihiro, Hayashi, Kok Hoong, Leong, Shungo, Kumada, Yoshinori, Onuki
Rok vydání:	2022
Předmět:	Magnetic Resonance Spectroscopy Time Factors Calorimetry Differential Scanning Pharmaceutical Preparations X-Ray Diffraction Drug Discovery Salts General Chemistry General Medicine
Zdroj:	Chemical and Pharmaceutical Bulletin. 70:162-168
ISSN:	1347-5223 0009-2363
Popis:	NMR relaxometry measurement by time domain NMR (TD-NMR) is a promising technique for characterizing the properties of active pharmaceutical ingredients (APIs). This study is dedicated to identifying the salt and free base of APIs by NMR relaxometry measured by the TD-NMR technique. Procaine (PC) and tetracaine (TC) were selected as model APIs to be tested. By using conventional methods including powder X-ray diffraction and differential scanning calorimetry, this study first confirmed that the salt and free base of the tested APIs differ from each other in their crystalline form. Subsequently, measurements of T
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edd46c95d3273e982c89190d64c028b6 https://doi.org/10.1248/cpb.c21-00975 Zobrazit plný text záznamu