A randomized controlled trial of artemotil (beta-arteether) in Zambian children with cerebral malaria
| Autor: | P. A. M. Peeters, C. Osborne, V. R. Gordeuk, C. B. Lugt, Philip E. Thuma, G. F. Mabeza, B. Oosterhuis, Godfrey Biemba, G. M. Shakankale, G. J. Bhat |
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| Rok vydání: | 2001 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Artemotil Malaria Cerebral Zambia Injections Intramuscular law.invention Antimalarials Randomized controlled trial law Virology parasitic diseases medicine Humans Prospective Studies Prospective cohort study Child Survival rate Coma Quinine business.industry Infant Newborn Infant medicine.disease Artemisinins Surgery Survival Rate Infectious Diseases Cerebral Malaria Child Preschool Parasitology Female medicine.symptom business Sesquiterpenes Malaria medicine.drug |
| Zdroj: | The American journal of tropical medicine and hygiene. 62(4) |
| ISSN: | 0002-9637 |
| Popis: | The efficacy and safety of intramuscular artemotil (ARTECEF) was compared to intravenous quinine in African children with cerebral malaria. This prospective block randomized open-label study was conducted at two centers in Zambia. Subjects were children aged 0 to 10 years of age with cerebral malaria and a Blantyre Coma Score of 2 or less. Ninety two children were studied; 48 received artemotil and 44 quinine. No significant differences in survival, coma resolution time, neurologic sequelae, parasite clearance time, and fever resolution time were seen between the two regimens. Rates for negative malaria smears one month after therapy were similar in both groups. Artemotil was a well-tolerated drug in the 48 patients in this study. It appears to be at least therapeutically equivalent to quinine for the treatment of pediatric cerebral malaria. It has the advantage of being able to be given intramuscularly once daily for only five days. |
| Databáze: | OpenAIRE |
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