Metal Chelate Compounds with Tetracycline Derivatives. VII. : The Structure of Tetracycline Chelates
| Autor: | Hiroshi Omura, Tomoko Yoshida, Takeichi Sakaguchi, Hisashi Takasu, Masahiko Toma |
|---|---|
| Rok vydání: | 1958 |
| Předmět: |
Zirconium
Tetracycline Inorganic chemistry Thorium chemistry.chemical_element Oxytetracycline Metal chelate General Chemistry General Medicine Anti-Bacterial Agents chemistry Metals Tetracyclines Molar ratio Drug Discovery medicine Chelation Achromycin Chelating Agents Chlortetracycline Nuclear chemistry medicine.drug |
| Zdroj: | Chemical and Pharmaceutical Bulletin. 6:1-9 |
| ISSN: | 1347-5223 0009-2363 |
| DOI: | 10.1248/cpb.6.1 |
| Popis: | Terramycin and Achromycin form chelate compounds with various metals, especially stable compounds with zirconium and thorium, as previously reported with Aureomycin. Their molar ratio is 1:1 in thorium chelates and 1:2 in zirconium chelates. Further investigations on the chelate formation of Apoterramycin and Isoaureomycin showed that phenolic β-diketone in tetracycline structure was very important as the chelating group, as was indicated in the previous paper. It is also suggested that the chelation of tetracylines must further involve the 12-1 bond. |
| Databáze: | OpenAIRE |
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