The alpha1-adrenergic receptors in cardiac hypertrophy: Signaling mechanisms and functional implications
| Autor: | Cosmo D. del Vescovo, Stefania Caso, Matilde Colella, Dario Diviani, Susanna Cotecchia |
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| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Ventricular Remodeling Adrenergic receptor Mechanism (biology) Myocardium Cardiomegaly Cell Biology Biology medicine.disease Muscle hypertrophy Human morbidity Endocrinology Receptors Adrenergic alpha-1 Internal medicine Heart failure medicine Animals Humans Myocytes Cardiac Signal transduction Receptor Neuroscience Signal Transduction G protein-coupled receptor |
| Zdroj: | Cellular Signalling. 27:1984-1993 |
| ISSN: | 0898-6568 |
| DOI: | 10.1016/j.cellsig.2015.06.009 |
| Popis: | Cardiac hypertrophy is a complex remodeling process of the heart induced by physiological or pathological stimuli resulting in increased cardiomyocyte size and myocardial mass. Whereas cardiac hypertrophy can be an adaptive mechanism to stressful conditions of the heart, prolonged hypertrophy can lead to heart failure which represents the primary cause of human morbidity and mortality. Among G protein-coupled receptors, the α1-adrenergic receptors (α1-ARs) play an important role in the development of cardiac hypertrophy as demonstrated by numerous studies in the past decades, both in primary cardiomyocyte cultures and genetically modified mice. The results of these studies have provided evidence of a large variety of α1-AR-induced signaling events contributing to the defining molecular and cellular features of cardiac hypertrophy. Recently, novel signaling mechanisms have been identified and new hypotheses have emerged concerning the functional role of the α1-adrenergic receptors in the heart. This review will summarize the main signaling pathways activated by the α1-AR in the heart and their functional implications in cardiac hypertrophy. |
| Databáze: | OpenAIRE |
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