Biochemical and histopathological responses in Nile tilapia exposed to a commercial insecticide mixture containing dinotefuran and lambda-cyhalothrin
Autor: | Alaide Cristina de Bem Matos, Caroline Kuhnen Lima, Mariele Abadia Elias, Indianara Fernanda Barcarolli, Carla Ivane Ganz Vogel, Karim Hahn Lüchmann |
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Rok vydání: | 2022 |
Předmět: |
Gills
Insecticides Physiology Health Toxicology and Mutagenesis Cell Biology General Medicine Cichlids gamma-Glutamyltransferase Toxicology Alkaline Phosphatase Nitro Compounds Biochemistry Guanidines Neonicotinoids Oxidative Stress Liver Nitriles Pyrethrins Acetylcholinesterase Animals Biomarkers Water Pollutants Chemical Glutathione Transferase |
Zdroj: | Comparative biochemistry and physiology. Toxicologypharmacology : CBP. 262 |
ISSN: | 1532-0456 |
Popis: | The indiscriminate use of pesticides has led to an increased risk of environmental contamination and pest resistance worldwide, favoring the development of less hazardous formulations. The commercial insecticide ZEUS® (Ihara, Brazil) combining dinotefuran and lambda-cyhalothrin was recently formulated in order to meet the environmental sustainability and food security. However, little is known about the potential toxic effects of ZEUS® to aquatic species. Thus, we report, for the first time, the biochemical and histological responses in tilapia (Oreochromis niloticus) following 96 h exposure to 0.01 mg/L, 0.05 mg/L and 0.1 mg/L ZEUS®. Different biochemical endpoints, including acetylcholinesterase (AChE), gamma-glutamyltransferase (GGT) and alkaline phosphatase (ALP), were assessed as potential biomarkers of insecticide effects. Glutathione S-transferase (GST) was evaluated as a marker of phase II biotransformation, and histopathological changes were measured to indicate gill alterations following ZEUS® exposure. After 96 h exposure, ZEUS® treatment increased GST activity in the liver of fish exposed to the highest concentration, while the intermediate dose increased both renal GGT and hepatic ALP activities. These findings reflect the importance of the liver and kidneys in the detoxification of ZEUS® and highlight the need to understand further toxicity effects. Likewise, the histopathological analysis of gills provided evidence that ZEUS® caused moderate damages. Despite biomarkers alterations reported for O. niloticus following ZEUS® exposure, by comparing our findings with data on toxicity of individual compounds, the commercial ZEUS® mixture seems to present similar or even lower adverse effects on freshwater fish. |
Databáze: | OpenAIRE |
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