Localized microbubble cavitation-based antivascular therapy for improving HCC treatment response to radiotherapy
| Autor: | Flemming Forsberg, Jie Zhang, Maria Stanczak, Ji-Bin Liu, Dennis B. Leeper, Shisuo Du, John R. Eisenbrey, Annemarie Daecher |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Cancer Research Treatment response medicine.medical_specialty Carcinoma Hepatocellular Radiofrequency ablation medicine.medical_treatment Malignancy Article law.invention 03 medical and health sciences Random Allocation Rats Nude 0302 clinical medicine law Cell Line Tumor medicine Animals Humans Survival rate Right liver lobe Microbubbles Neovascularization Pathologic business.industry Liver Neoplasms medicine.disease Xenograft Model Antitumor Assays High-intensity focused ultrasound Rats Radiation therapy 030104 developmental biology Oncology 030220 oncology & carcinogenesis Hepatocellular carcinoma Radiology business |
| Popis: | Hepatocellular carcinoma (HCC) is the third leading cause of cancer mortality worldwide and the fastest growing malignancy in the United States. With a 5-year survival rate below 12%, effective therapies for HCC are needed. Current treatments for HCC include microwave and radiofrequency ablation, high intensity focused ultrasound, liver transplant, surgical resection, and localized embolizations. However, each of these approaches has some limitation, making it imperative to develop improved methods for sensitizing tumors prior to therapy. We hypothesized that the use of ultrasound-triggered microbubble destruction (UTMD), which sensitizes tumors to radiotherapy by inducing vascular endothelial cell apoptosis, will selectively sensitize malignant tissue to radiotherapy and improve outcomes. To test this, 18 nude rats were inoculated in the right liver lobe with Hu7.5 HCC cells and after tumor formation, received 5 Gy radiotherapy, UTMD, or UTMD prior to radiotherapy. Compared to radiotherapy alone, there was a 170% reduction in tumor growth 7 days post treatment and a 3.2X improvement in median survival time when radiotherapy was combined with UTMD. These results indicate that UTMD is an effective adjunct when combined with radiotherapy to treat HCC. |
| Databáze: | OpenAIRE |
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