Regulatory T Cell Function Modulated After Successful Direct-Acting Antiviral Treatment for Chronic Hepatitis C Patients
| Autor: | Shu-Fen Wu, Kuo-Chih Tseng, Yen-Chun Chen, Yun-Che Ho, Yi-Ting He, Ping-Hung Ko, Chih-Wei Tseng |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Genotype Sustained Virologic Response Physiology Regulatory T cell Hepacivirus Gastroenterology Antiviral Agents T-Lymphocytes Regulatory Pathogenesis 03 medical and health sciences 0302 clinical medicine Interferon Internal medicine medicine Humans Aged business.industry FOXP3 Hepatitis C Hepatology Hepatitis C Chronic Middle Aged medicine.disease Fold change medicine.anatomical_structure 030220 oncology & carcinogenesis Cytokines RNA Viral 030211 gastroenterology & hepatology Tumor necrosis factor alpha Female business medicine.drug |
| Zdroj: | Digestive diseases and sciences. 65(5) |
| ISSN: | 1573-2568 |
| Popis: | Regulatory T cells (Tregs) affect the pathogenesis of chronic hepatitis C (CHC) infection. This study evaluated the function of Tregs in CHC patients receiving the standard direct-acting antiviral agents (DAA) treatment. CHC patients (n = 20) who received DAA treatment, clinical data, and function of Tregs were checked at baseline, Week 4, end of treatment (EOT), and 12 weeks after EOT (SVR 12). Treg-mediated inhibition was measured. The cytokine expression and fold change of interferon (IFN)-γ, tumor necrosis factor (TNF)-α, IL-10, and transforming growth factor (TGF)-β with/without Treg inhibition were also detected. The cohort included 14 females with a mean age of 59.8 ± 11.5 years. Nineteen had HCV genotype 1. The HCV RNA level was 6.17 ± 0.70 log IU/mL. All patients reached the sustained virologic response. The frequency of CD4+Foxp3+T cells decreased from baseline to EOT and returned at SVR 12. The inhibitory function of Tregs decreased during treatment and then restored (baseline vs. EOT, P = 0.0393; EOT vs. SVR 12, P = 0.0052). The cytokine expression and fold change of IFN-γ and TNF-α were highest at EOT and then decreased at SVR 12. The fold change of IL-10 was lowest at EOT and then increased at SVR 12. The fold change of TGF-β was significantly increased at Week 4 and SVR 12 compared to baseline. The frequency and inhibitory function of Tregs declined gradually from baseline to EOT and then increased from EOT to SVR 12 in CHC patients receiving DAA therapy. The expression of IFN-γ, TNF-α, IL-10, and TGF-β parallelled Treg function. |
| Databáze: | OpenAIRE |
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