Bone Marrow Mesenchymal Stem Cell-Derived Tissues are Mechanically Superior to Meniscus Cells
| Autor: | Aillette Mulet-Sierra, Mark Sommerfeldt, Xiaoyi Lan, Alexander R A Szojka, Adetola B Adesida, Hoda Elkhenany, Melanie Kunze, Nadr M. Jomha, Yan Liang |
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| Rok vydání: | 2021 |
| Předmět: |
musculoskeletal diseases
Pathology medicine.medical_specialty 0206 medical engineering Biomedical Engineering Bone Marrow Cells Bioengineering 02 engineering and technology Meniscus (anatomy) Knee Joint Biochemistry Biomaterials 03 medical and health sciences 3D cell culture stomatognathic system Tissue engineering medicine Humans Meniscus Cells Cultured 030304 developmental biology 0303 health sciences Tissue Engineering Tissue Scaffolds Chemistry Mesenchymal stem cell Mesenchymal Stem Cells musculoskeletal system 020601 biomedical engineering medicine.anatomical_structure Bone marrow Chondrogenesis Collagen scaffold |
| Zdroj: | Tissue Engineering Part A. 27:914-928 |
| ISSN: | 1937-335X 1937-3341 |
| DOI: | 10.1089/ten.tea.2020.0183 |
| Popis: | Bone marrow-derived mesenchymal stem cells (BMSCs) have the potential to form the mechanically responsive matrices of joint tissues, including the menisci of the knee joint. The purpose of this study is to assess BMSC's potential to engineer meniscus-like tissue relative to meniscus fibrochondrocytes (MFCs). MFCs were isolated from castoffs of partial meniscectomy from nonosteoarthritic knees. BMSCs were developed from bone marrow aspirates of the iliac crest. All cells were of human origin. Cells were cultured in type I collagen scaffolds under normoxia (21% O |
| Databáze: | OpenAIRE |
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