Biological evaluation of secondary metabolites from the roots of Myrica adenophora
| Autor: | Hui-Chun Wang, Ih-Sheng Chen, Hsun-Shuo Chang, Ya-Chih Ting, Chien-Fang Peng, Horng-Huey Ko, Pei-Chen Hsieh |
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| Rok vydání: | 2014 |
| Předmět: |
DPPH
Stereochemistry Plant Science Horticulture Myrica Plant Roots Biochemistry Antioxidants Myricaceae chemistry.chemical_compound Picrates Diarylheptanoids Proanthocyanidins Glycosides Molecular Biology Flavonoids chemistry.chemical_classification Chromatography ABTS Molecular Structure biology Biphenyl Compounds Diarylheptanoid Glycoside Free Radical Scavengers General Medicine biology.organism_classification Adenophora chemistry Myricetin |
| Zdroj: | Phytochemistry. 103:89-98 |
| ISSN: | 0031-9422 |
| Popis: | Bioassay-guided fractionation of the roots of Myrica adenophora led to isolation of 24 known compounds and hitherto unknown compounds, including three A-type proanthocyanidins [adenodimerins A-C], two esters of sucrose [myricadenins A and B ], and the phenolic glycoside 6'-O-galloyl orbicularin. Spectroscopic analyses were used to determine their structures. Adenodimerin A, myricananin C, and myricetin showed strong 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activities, with SC50 values of 7.9, 16.3, and 15.9 μM, respectively. Adenodimerin A, myricanone, myricananin C, (-)-myricanol, myricanol 11-O-β-D-glucopyranoside, and myricetin showed stronger 2,2'-azino-bis-3-ethylbenzthiazoline-6-sulphonic acid (ABTS) radical scavenging activities than the positive control, with SC50 values of 7.5, 19.6, 12.0, 22.3, 19.6, and 15.6 μM, respectively. 5-Deoxymyricanone, porson, 12-hydroxymyricanone (-)-myricanol, and (+)-galeon exhibited anti-tubercular activity against Mycobacterium tuberculosis H37Rv in vitro and MICs values of 25.8, 40.0, 35.8, 30.0, and 15.0 μg/mL, respectively. Myricadenin A, myricanone, myricananin C, and (-)-myricanol exhibited anti-inflammatory activities in the iNOS assay with EC50 values of 18.1, 1.00, 13.0, and 7.5 μM, respectively. |
| Databáze: | OpenAIRE |
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