Daptomycin-loaded biodegradable thermosensitive hydrogels enhance drug stability and foster bactericidal activity against Staphylococcus aureus

Autor: Maria Eugenia Butini, Roberta Censi, Piera Di Martino, Mariagrazia Di Luca, Cristina Casadidio, Andrej Trampuz
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
Staphylococcus aureus
Time Factors
medicine.drug_class
Chemistry
Pharmaceutical
030106 microbiology
Antibiotics
Pharmaceutical Science
Microbial Sensitivity Tests
macromolecular substances
medicine.disease_cause
Polyethylene Glycols
Antibiotic controlled release
Daptomycin
Implant-associated infections
Staphylococcal biofilm
Thermosensitive hydrogels
Anti-Bacterial Agents
Biofilms
Drug Carriers
Drug Liberation
Drug Stability
Hyaluronic Acid
Hydrogels
Polymethacrylic Acids
Temperature
Drug Delivery Systems
Biotechnology
3003
03 medical and health sciences
chemistry.chemical_compound
Hyaluronic acid
medicine
Antibiotic controlled releaseThermosensitive hydrogelsStaphylococcal biofilmDaptomycinImplant-associated infections
Chemistry
Biofilm
Lipopeptide
General Medicine
Combinatorial chemistry
Drug delivery
Self-healing hydrogels
Pharmaceutical
medicine.drug
Zdroj: European journal of pharmaceutics and biopharmaceutics 130 (2018): 260–271. doi:10.1016/j.ejpb.2018.07.001
info:cnr-pdr/source/autori:Casadidio C.; Butini M.E.; Trampuz A.; Di Luca M.; Censi R.; Di Martino P./titolo:Daptomycin-loaded biodegradable thermosensitive hydrogels enhance drug stability and foster bactericidal activity against Staphylococcus aureus/doi:10.1016%2Fj.ejpb.2018.07.001/rivista:European journal of pharmaceutics and biopharmaceutics/anno:2018/pagina_da:260/pagina_a:271/intervallo_pagine:260–271/volume:130
European Journal of Pharmaceutics and Biopharmaceutics
DOI: 10.1016/j.ejpb.2018.07.001
Popis: A drug delivery system based on fully biodegradable thermosensitive hydrogels enabling controlled antibiotic release may support the management of implant-associated infections. In this work, the lipopeptide antibiotic daptomycin was encapsulated in hydrogel networks consisting of vinyl sulfonated triblock copolymers of PEG-p(HPMAm-lac1,2) and thiolated hyaluronic acid. High concentrations of active daptomycin exceeding the minimum biofilm eradicating concentration were sustainably eluted from the biodegradable carrier. The drug release profiles were tailored by varying the degree of substitution (DS) of thiol groups of hyaluronic acid, reaching a plateau level after 200 and 330 h for DS values of 53% and 31%, respectively. The hydrogel polymeric network preserved the structural stability of the loaded antibiotic and retained the calcium-dependent daptomycin activity, showing a noticeable biofilm bactericidal effect against a 24 h-old Staphylococcus aureus biofilm in vitro. The two-component thermosensitive hydrogels demonstrated to be an excellent antibiotic releasing scaffold with potential clinical applications in the management of implant-associated infections.
Databáze: OpenAIRE
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