Structure and function of minor pilins of type IV pili

Autor: Nadia Izadi-Pruneyre, Benjamin Bardiaux, Theis Jacobsen, Olivera Francetic, Michael Nilges
Přispěvatelé: Bioinformatique structurale - Structural Bioinformatics, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), ED 515 - Complexité du vivant, Sorbonne Université (SU), Biochimie des Interactions Macromoléculaires / Biochemistry of Macromolecular Interactions, This work was funded by the French Agence Nationale de la Recherche (ANR-14-CE09-0004 to OF), the INCEPTION project (PIA/ANR-16-CONV-0005), the FRM (Equipe FRM 2017 M.DEQ 20170839114 to MN) and the European Union’s Horizon 2020 Research and Innovation Programme under the Marie Sklodowska-Curie Grant agreement 765042., We are grateful to the Institut Pasteur and the CNRS for their continued support for our research., ANR-14-CE09-0004,FiberSpace,Pili de type IV et pseudopili: structure, dynamique, assemblage et fonction moléculaire(2014), ANR-16-CONV-0005,INCEPTION,Institut Convergences pour l'étude de l'Emergence des Pathologies au Travers des Individus et des populatiONs(2016), European Project: 765042,H2020-EU.1.3.1. - Fostering new skills by means of excellent initial training of researchers ,ViBrANT(2018), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)
Jazyk: angličtina
Rok vydání: 2019
Předmět:
0301 basic medicine
Microbiology (medical)
Minor pilins
Models
Molecular
Protein Conformation
Protein subunit
030106 microbiology
Immunology
Virulence
Review
medicine.disease_cause
Pilus
Bacterial Adhesion
Microbiology
03 medical and health sciences
chemistry.chemical_compound
medicine
Type IV pili
Immunology and Allergy
[SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry
Molecular Biology/Biochemistry [q-bio.BM]
Type II secretion system
biology
Host Microbial Interactions
Neisseria meningitidis
Pathogenic bacteria
General Medicine
biochemical phenomena
metabolism
and nutrition
biology.organism_classification
[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology
030104 developmental biology
[SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology
chemistry
Fimbriae
Bacterial
Adhesion
bacteria
Fimbriae Proteins
Protein Multimerization
Bacteria
DNA
Zdroj: Medical Microbiology and Immunology
Medical Microbiology and Immunology, Springer Verlag, 2019, ⟨10.1007/s00430-019-00642-5⟩
Medical Microbiology and Immunology, 2019, ⟨10.1007/s00430-019-00642-5⟩
ISSN: 1432-1831
0300-8584
DOI: 10.1007/s00430-019-00642-5⟩
Popis: Type IV pili are versatile and highly flexible fibers formed on the surface of many Gram-negative and Gram-positive bacteria. Virulence and infection rate of several pathogenic bacteria, such as Neisseria meningitidis and Pseudomonas aeruginosa, are strongly dependent on the presence of pili as they facilitate the adhesion of the bacteria to the host cell. Disruption of the interactions between the pili and the host cells by targeting proteins involved in this interaction could, therefore, be a treatment strategy. A type IV pilus is primarily composed of multiple copies of protein subunits called major pilins. Additional proteins, called minor pilins, are present in lower abundance, but are essential for the assembly of the pilus or for its specific functions. One class of minor pilins is required to initiate the formation of pili, and may form a complex similar to that identified in the related type II secretion system. Other, species-specific minor pilins in the type IV pilus system have been shown to promote additional functions such as DNA binding, aggregation and adherence. Here, we will review the structure and the function of the minor pilins from type IV pili.
Databáze: OpenAIRE
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