Stem Cell Therapy in the Treatment of Patients With Autism Spectrum Disorder: a Systematic Review and Meta-analysis

Autor:	Laura Villarreal-Martínez, David Alejandro Robles-Sáenz, Adrián González-Martínez, Elizabeth Garza-López, Andrea Judith Bautista-Gómez, Miguel Ortiz-Castillo, Gerardo González-Martínez, Melissa Sáenz-Flores
Rok vydání:	2021
Předmět:	medicine.medical_specialty Autism Spectrum Disorder business.industry medicine.medical_treatment Cell- and Tissue-Based Therapy MEDLINE Stem-cell therapy Placebo medicine.disease Autism spectrum disorder Meta-analysis Internal medicine medicine Humans Autism Stem cell Adverse effect business
Zdroj:	Stem Cell Reviews and Reports. 18:155-164
ISSN:	2629-3277 2629-3269
Popis:	Assess the safety and efficacy of upcoming stem cell treatments and analyze their effects on the cognitive and behavioral impairments in patients diagnosed with autism. We included controlled and noncontrolled, randomized and non-randomized trials evaluating stem cell therapy as a treatment in patients with autism spectrum disorder compared to placebo or without comparator. Data Sources: Scopus, Web of Science, MEDLINE and EMBASE. Risk of bias was assessed using Cochrane’s Risk of Bias tool and the NIH’s Quality Assessment Tool for Studies With No Control Group. Eleven trials including 461 patients proved eligible. ABC scale meta-analysis showed a mean raw of -11.97 in the intervention groups (95 % CI -91.45 to 67.52, p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edc90c8d630a05c414fa153a6abb0696 https://doi.org/10.1007/s12015-021-10257-0 Zobrazit plný text záznamu Full text from SpringerLink