Cross-linking chitosan-Fe(III), an oral phosphate binder: studies in vitro and in vivo
| Autor: | Silvana Sandri, Daniela Valcarenghi, Clóvis Antonio Rodrigues, Cristiani Bürger |
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| Rok vydání: | 2001 |
| Předmět: |
Male
Chitosan medicine.drug_class Iron Pharmaceutical Science Chitin Hydrogen-Ion Concentration Phosphate medicine.disease In vitro Phosphate binder Phosphates Rats chemistry.chemical_compound Hyperphosphatemia Iron sulfate chemistry Biochemistry In vivo medicine Animals Rats Wistar Nuclear chemistry |
| Zdroj: | International journal of pharmaceutics. 223(1-2) |
| ISSN: | 0378-5173 |
| Popis: | The objective was to evaluate the in vitro and in vivo phosphate binding properties of cross-linked chitosan iron (III) (CH-Fe(III)-CL), a potential oral phosphate binder for treating hyperphosphatemia. At equilibrium, the in vitro phosphate binding of CH-Fe(III)-CL was 23.6 mg g(-1) for simulated gastrointestinal conditions. In hyperphosphatemic rats, CH-Fe(III)-CL was similar to iron sulfate in reducing serum phosphate by about 35%. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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