Y3+ embedded in polymeric nanoparticles: Morphology, dimension and stability of composite colloidal system
| Autor: | Antonella Cartoni, R. Faccini, Francesca A. Scaramuzzo, Laura Fontana, T. Scotognella, Iole Venditti, Valentina Dini, Ilaria Fratoddi, Federica Marini, C. Mancini Terracciano, S. Morganti, Alessandro Giordano, Giovanna Testa, E. Solfaroli Camillocci, Dante Rotili |
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| Přispěvatelé: | Venditti, Iole, Cartoni, A., Fontana, L., Testa, G., Scaramuzzo, F. A., Faccini, R., Terracciano, C. M., Camillocci, E. S., Morganti, S., Giordano, A., Scotognella, T., Rotili, D., Dini, V., Marini, F., Fratoddi, I. |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Materials science
Polymethylmethacrylate Composite number Emulsion polymerization Nanoparticle 02 engineering and technology Polymeric nanoparticle 010402 general chemistry 01 natural sciences chemistry.chemical_compound Colloid Colloid and Surface Chemistry Polymer chemistry Yttrium Radiolabeled nanoparticle Nanostructured composite Nanostructured composites Polymeric nanoparticles Radiolabeled nanoparticles Nanocomposite Potassium persulfate 021001 nanoscience & nanotechnology 0104 chemical sciences Chemical engineering chemistry Diethylenetriamine Radical initiator 0210 nano-technology |
| Popis: | Radiolabeled nanoparticles are promising tools in cancer diagnosis and therapy. Moreover, yttrium-90 (90Y) is a good candidate as suitable β− emitting radioisotope for a new approach to radio-guided surgery (RGS) proposed by some researchers of our group. In this work, we developed new composite nanoparticles, based on polymethylmethacrylate (PMMA), and poly(methylmethacrylate-co-acrylic acid), P(MMA/AA), embedded with yttrium ion (89Y3+), as a first step for the development of new 90Y3+ based nanocomposites. The composite nanoparticles were synthesised by emulsion polymerization technique, in the presence of potassium persulfate (KPS) as radical initiator, toluene as cosolvent, diethylenetriamine penta acetic acid dianhydride (DTPA) as chelating agent, using different MMA/89Y3+ molar ratios. The yttrium doped polymeric nanoparticles were characterized by means of FTIR spectroscopy, SEM-EDX, AFM, and DLS measurements. The influence of experimental parameters, such as cosolvent and reaction time, on morphology and dimension of composite nanoparticles was investigated, and monodispersed nanospheres with diameters from 20 nm to 400 nm were obtained. The composite material was purified and studied by means of DLS to confirm the colloid stability in water solution at different temperatures (25 °C and 37 °C) up to 3 weeks. |
| Databáze: | OpenAIRE |
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