Mid-regional proadrenomedullin, C-terminal proendothelin-1 values, and disease course are not different in critically ill SARS-CoV-2 pneumonia patients with obesity

Autor: Jos A. H. van Oers, Sjaak Pouwels, Dharmanand Ramnarain, Yvette Kluiters, Judith A. P. Bons, Dylan W. de Lange, Harm-Jan de Grooth, Armand R. J. Girbes
Přispěvatelé: MUMC+: DA CDL Algemeen (9), RS: NUTRIM - R3 - Respiratory & Age-related Health, Intensive care medicine, ACS - Microcirculation, ACS - Diabetes & metabolism, AII - Infectious diseases
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: International Journal of Obesity, 46(10), 1801-1807. Nature Publishing Group
van Oers, J A H, Pouwels, S, Ramnarain, D, Kluiters, Y, Bons, J A P, de Lange, D W, de Grooth, H-J & Girbes, A R J 2022, ' Mid-regional proadrenomedullin, C-terminal proendothelin-1 values, and disease course are not different in critically ill SARS-CoV-2 pneumonia patients with obesity ', International Journal of Obesity, vol. 46, no. 10, pp. 1801-1807 . https://doi.org/10.1038/s41366-022-01184-2
ISSN: 1476-5497
0307-0565
DOI: 10.1038/s41366-022-01184-2
Popis: Background/objectives: Patients affected by obesity and Coronavirus disease 2019, the disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), appear to have a higher risk for intensive care (ICU) admission. A state of low-grade chronic inflammation in obesity has been suggested as one of the underlying mechanisms. We investigated whether obesity is associated with differences in new inflammatory biomarkers mid-regional proadrenomedullin (MR-proADM), C-terminal proendothelin-1 (CT-proET-1), and clinical outcomes in critically ill patients with SARS-CoV-2 pneumonia. Subjects/methods: A total of 105 critically ill patients with SARS-CoV-2 pneumonia were divided in patients with obesity (body mass index (BMI) ≥ 30 kg/m 2, n = 42) and patients without obesity (BMI < 30 kg/m 2, n = 63) and studied in a retrospective observational cohort study. MR-proADM, CT-proET-1 concentrations, and conventional markers of white blood count (WBC), C-reactive protein (CRP), and procalcitonin (PCT) were collected during the first 7 days. Results: BMI was 33.5 (32–36.1) and 26.2 (24.7–27.8) kg/m 2 in the group with and without obesity. There were no significant differences in concentrations MR-proADM, CT-proET-1, WBC, CRP, and PCT at baseline and the next 6 days between patients with and without obesity. Only MR-proADM changed significantly over time (p = 0.039). Also, BMI did not correlate with inflammatory biomarkers (MR-proADM rho = 0.150, p = 0.125, CT-proET-1 rho = 0.179, p = 0.067, WBC rho = −0.044, p = 0.654, CRP rho = 0.057, p = 0.564, PCT rho = 0.022, p = 0.842). Finally, no significant differences in time on a ventilator, ICU length of stay, and 28-day mortality between patients with or without obesity were observed. Conclusions: In critically ill patients with confirmed SARS-CoV-2 pneumonia, obesity was not associated with differences in MR-proADM, and CT-proET-1, or impaired outcome. Trial registration: Netherlands Trial Register, NL8460.
Databáze: OpenAIRE
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