Cystic fibrosis-related diabetes (CFRD) and cognitive function in adults with cystic fibrosis
| Autor: | Louise Dye, M.W. Mansfield, Daniel Peckham, H.K. Chadwick, Clare L. Lawton, Margaret Anne Hurley, Janice Abbott |
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| Rok vydání: | 2022 |
| Předmět: |
Adult
0301 basic medicine Pulmonary and Respiratory Medicine medicine.medical_specialty Cystic Fibrosis Cystic fibrosis-related diabetes C850 Audiology 03 medical and health sciences Cognition 0302 clinical medicine Diabetes Mellitus medicine Humans Effects of sleep deprivation on cognitive performance Prefrontal cortex business.industry Cambridge Neuropsychological Test Automated Battery Cognitive flexibility medicine.disease Cognitive test 030104 developmental biology 030228 respiratory system Pediatrics Perinatology and Child Health business Cognitive load |
| Zdroj: | Journal of Cystic Fibrosis. 21:519-528 |
| ISSN: | 1569-1993 |
| Popis: | Background Being able to function cognitively is imperative for successful achievement in school, working life, and disease self-management. Diabetes is known to cause changes in brain structure and long-term cognitive dysfunction. This work investigated cystic fibrosis-related diabetes (CFRD) as a mechanism for cognitive impairment in people with CF. It was hypothesised that cognition would be poorer in adults with CFRD than in those with CF without diabetes (CFND) or in healthy controls. Methods Cognitive performance was assessed using the Cambridge Neuropsychological Test Automated Battery which provides a comprehensive cognitive assessment with tests mapping onto specific brain regions. Demographic, clinical and self-reported health data were documented for all participants. CF specific clinical variables were recorded for the two CF groups. Results Ninety-eight people with CF (49CFRD,49CFND) and 49 healthy controls were recruited. People with CF demonstrated deficits in aspects of verbal and spatial memory, processing speed and cognitive flexibility compared with healthy controls, with all areas of the brain implicated. Those with CFRD had additional difficulties with higher-level processes known collectively as ‘executive function’, which demand greater cognitive load and recruit the prefrontal cortex. Compared with healthy controls, those with CFND and CFRD had an estimated 20% and up to 40% reduction in processing speed respectively. Conclusion Managing CF requires higher order executive function. Impairments may be sufficient to interfere with self-care and the ability to perform everyday tasks efficiently. At which point in the CF disease trajectory these difficulties begin, and what may attenuate them, has yet to be determined. |
| Databáze: | OpenAIRE |
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