Extending the application of a magnetic PEG three-part drug release device on a graphene substrate for the removal of Gram-positive and Gram-negative bacteria and cancerous and pathologic cells

Autor: H. Saligheh Rad, M Shafiee Ardestani, M Ramezani Farani, P Khadive Parsi, Gh. Riazi
Jazyk: angličtina
Rok vydání: 2019
Předmět:
0301 basic medicine
Pharmaceutical Science
PC12 Cells
Polyethylene Glycols
law.invention
chemistry.chemical_compound
0302 clinical medicine
law
Neoplasms
Drug Discovery
curcumin
Magnetite Nanoparticles
Original Research
Molecular Structure
Chemistry
Hep G2 Cells
humanities
Anti-Bacterial Agents
030220 oncology & carcinogenesis
graphene oxide
Graphite
Thermogravimetric analysis
Cell Survival
magnetic nanocomposite
Antineoplastic Agents
Ether
Microbial Sensitivity Tests
Gram-Positive Bacteria
03 medical and health sciences
Gram-Negative Bacteria
PEG ratio
Animals
Humans
MTT assay
Cell Proliferation
Pharmacology
Nanocomposite
Drug Design
Development and Therapy
Graphene
lcsh:RM1-950
Substrate (chemistry)
Rats
Drug Liberation
lcsh:Therapeutics. Pharmacology
030104 developmental biology
drug delivery
antimicrobial
Drug Screening Assays
Antitumor
Ethylene glycol
Nuclear chemistry
Zdroj: Drug Design, Development and Therapy
Drug Design, Development and Therapy, Vol Volume 13, Pp 1581-1591 (2019)
ISSN: 1177-8881
4563-1115
Popis: M Ramezani Farani,1 P Khadive Parsi,1 Gh Riazi,2 M Shafiee Ardestani,3 H Saligeh Rad4,5 1School of Chemical Engineering, University College of Engineering, University of Tehran, Tehran 4563-11155, Iran; 2Institute of Biophysics and Biochemistry, University of Tehran, Tehran 1417614411, Iran; 3Department of Radiopharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran; 4Quantitative Medical Imaging Systems Group, Research Center for Molecular and Cellular Imaging, Tehran University of Medical Sciences, Tehran, Iran; 5Medical Physics and Biomedical Engineering Department, Tehran University of Medical Sciences, Tehran, Iran Objective: In this study, novel graphene oxide (GO)-based nanocomposites are presented. In fact, we have tried to replace the carboxyl groups on the surface of GO with amine groups to allow the biocompatible poly(ethylene glycol) bis(carboxymethyl) ether (average Mn 600) polymer to bond through an amide bond. Materials and methods: The synthesis was conducted accurately according to final characterization experiments (Raman, X-ray diffraction [XRD], atomic force microscopy [AFM], X-ray photoelectron spectroscopy [XPS], thermogravimetric analysis [TGA], etc). The antimicrobial property of this nanocomposite was examined in Escherichia coli (ATCC 25922) as Gram-negative and Staphylococcus aureus (ATCC 25923) as Gram-positive bacterial species. Besides, curcumin (CUR) was added to the produced nanocomposite both as a promising anticancer drug and an antioxidant, the toxicity of which was then assessed on cellular-based HepG2 and pC12. Results: An intense increase in toxicity was detected by MTT assay. Conclusion: It can mainly be concluded that the nanocomposite synthesized in this study is capable of delivering drugs with antibacterial properties. Keywords: graphene oxide, magnetic nanocomposite, drug delivery, antimicrobial, curcumin
Databáze: OpenAIRE
Externí odkaz: