Stimulation of Midgut Stem Cell Proliferation and Differentiation by Insect Hormones and Peptides
| Autor: | Marcia J. Loeb, Raziel S. Hakim, Daan De Wilde, Guy Smagghe, Wendy Vanhassel, Shintaro Goto, Clarina Moeremans, Michael B. Blackburn |
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| Rok vydání: | 2005 |
| Předmět: |
Ecdysone
medicine.medical_specialty media_common.quotation_subject Cellular differentiation 20-Hydroxyecdysone Spodoptera General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound History and Philosophy of Science Internal medicine parasitic diseases medicine Animals Metamorphosis Cell Proliferation media_common Dose-Response Relationship Drug biology Cell growth Stem Cells General Neuroscience fungi Cell Differentiation Midgut biology.organism_classification Cell biology Gastrointestinal Tract Endocrinology chemistry Insect Hormones Insect Proteins Stem cell Peptides |
| Zdroj: | Annals of the New York Academy of Sciences. 1040:472-475 |
| ISSN: | 0077-8923 |
| DOI: | 10.1196/annals.1327.094 |
| Popis: | Stem cells derived from midguts of the caterpillar, Spodoptera littoralis, can be induced to multiply and differentiate in vitro. Ecdysone (E) and 20-hydroxyecdysone (20E) had a concentration-dependent effect: E was more active in cell proliferation and 20E in differentiation. Ecdysteroid receptors in midgut stem cell nuclei were stained with the antibody 9B9. In addition, alpha-arylphorin and four midgut differentiation factors (MDF) specifically stimulated proliferation and differentiation of stem cells, respectively. The activity of a panel of peptide growth factors and hormones on growth and metamorphosis of the insect midgut is discussed. |
| Databáze: | OpenAIRE |
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