Comparative study of sucralfate 2 grams twice daily versus sucralfate 1 gram four times daily in the treatment of benign gastric ulcers in outpatients
| Autor: | Pettengell Ke, Spitaels Jm, Simjee Ae |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Sucralfate Bedtime Gastroenterology Endoscopy Gastrointestinal law.invention Randomized controlled trial Double-Blind Method law Internal medicine Ambulatory Care Medicine Humans Prospective Studies Stomach Ulcer Prospective cohort study Aged Chemotherapy Wound Healing business.industry Stomach General Medicine Middle Aged Regimen medicine.anatomical_structure Before Breakfast Patient Compliance Female business medicine.drug |
| Zdroj: | The American journal of medicine. 91(2A) |
| ISSN: | 0002-9343 |
| Popis: | In a double-blind, randomized study, we compared the healing of gastric ulcer during a twice-daily regimen of 2 g sucralfate or sucralfate 1 g q.i.d. Patients receiving the former therapy received the tablets one-half hour before breakfast and at bedtime. Patients receiving sucralfate 1 g q.i.d. received their therapy 30 minutes before breakfast, lunch, and supper, and at bedtime. The study included 52 patients with endoscopically proven gastric ulcer; 41 patients completed the study. Healing was endoscopically assessed at 8 weeks and 12 weeks. After 8 and 12 weeks the healing rate for sucralfate 2 g b.i.d. was 67% and 92%, respectively; the healing rate of sucralfate 1 g q.i.d. was 59% and 71%, respectively. No statistically significant difference was found between the two regimens. The results suggest that 2 g sucralfate twice daily is as effective in the healing of gastric ulcer as 1 g sucralfate q.i.d. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|