Computerized quantification of ultrasonic heterogeneity in thyroid nodules
| Autor: | Ming-Hsun Wu, Ming-Chih Ho, Argon Chen, Yu-Hsin Wang, Hao-Chih Tai, Chiung-Nien Chen, Kuen-Yuan Chen, Wen Hong Kuo, Wen Chang Huang, King-Jen Chang |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Thyroid nodules
Male medicine.medical_specialty Acoustics and Ultrasonics Biophysics Thyroid Gland Surgical pathology medicine Image Processing Computer-Assisted Humans Radiology Nuclear Medicine and imaging Prospective Studies Thyroid Nodule Thyroid cancer Grading (tumors) Ultrasonography Radiological and Ultrasound Technology business.industry Thyroid Ultrasound Reproducibility of Results Middle Aged medicine.disease medicine.anatomical_structure Computer-aided diagnosis Ultrasonic sensor Female Radiology business |
| Zdroj: | Ultrasound in medicinebiology. 40(11) |
| ISSN: | 1879-291X |
| Popis: | To test whether computerized quantification of ultrasonic heterogeneity can be of help in the diagnosis of thyroid malignancy, we evaluated ultrasonic heterogeneity with an objective and quantitative computerized method in a prospective setting. A total of 400 nodules including 271 benign thyroid nodules and 129 malignant thyroid nodules were evaluated. Patient clinical data were collected, and the grading of heterogeneity on conventional gray-scale ultrasound images was retrospectively reviewed by a thyroid specialist. Quantification of ultrasonic heterogeneity (heterogeneity index, HI) was performed by a proprietary program implemented with methods proposed in this article. HI values differed significantly between benign and malignant nodules, diagnosed by a combination of fine-needle aspiration and surgical pathology results (p < 0.001, area under the curve = 0.714). The ultrasonic heterogeneity of these samples, as assessed by an experienced clinician, could not significantly differentiate between benign and malignant thyroid nodules. However, nodules with marked ultrasonic heterogeneity had higher HI values than nodules with homogeneous nodules. These results indicate that the new computer-aided diagnosis method for evaluation of the ultrasonic heterogeneity of thyroid nodules is an objective and quantitative method that is correlated with conventional ultrasonic heterogeneity assessment, but can better aid in the diagnosis of thyroid malignancy. |
| Databáze: | OpenAIRE |
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