Insulin pump therapy is associated with less post-exercise hyperglycemia than multiple daily injections: an observational study of physically active type 1 diabetes patients
| Autor: | Jane E. Yardley, Bruce A. Perkins, Ronald J. Sigal, Michael C. Riddell, Katherine E. Iscoe, Glen P. Kenny |
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| Rok vydání: | 2012 |
| Předmět: |
Insulin pump
Adult Blood Glucose Male medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Injections Subcutaneous Drug Administration Schedule Endocrinology Insulin Infusion Systems Internal medicine Diabetes mellitus Post exercise medicine Aerobic exercise Humans Hypoglycemic Agents Insulin Exercise Aerobic capacity Glycated Hemoglobin Type 1 diabetes integumentary system business.industry Infusion Pumps Implantable medicine.disease Medical Laboratory Technology Diabetes Mellitus Type 1 Anesthesia Hyperglycemia Observational study Female business |
| Zdroj: | Diabetes technologytherapeutics. 15(1) |
| ISSN: | 1557-8593 |
| Popis: | Aerobic exercise typically decreases blood glucose levels in individuals with type 1 diabetes. It is currently unknown if glucose responses to exercise and recovery differ between patients on multiple daily insulin injections (MDI) and continuous subcutaneous insulin infusion (CSII).Nineteen (16 male, three female) physically active individuals with type 1 diabetes took part in this observational study. Interstitial glucose levels (blinded) were compared during 45 min of standardized aerobic exercise (cycling or running at 60% peak aerobic capacity) and during 6 h of postexercise recovery between individuals using MDI (n=9) and CSII (n=10) therapy.Both MDI and CSII groups had similar reductions in glucose levels during exercise, but responses in early and late recovery differed (group × time interaction, P0.01). Participants using MDI had greater increases in glucose throughout recovery compared with individuals with CSII. Two-thirds of the MDI patients experienced late-onset post-exercise hyperglycemia (blood glucose12 mmol/L) compared with only 1/10(th) of the CSII patients (P0.01).Among individuals performing regular moderate-to-heavy intensity aerobic exercise, use of CSII helped to limit post-exercise hyperglycemia compared with MDI therapy and is not associated with increased risk for post-exercise late-onset hypoglycemia. |
| Databáze: | OpenAIRE |
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